Susceptibility of Human Bone Marrow Cells and Hematopoietic Cell Lines to Coxsackievirus B3 Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Dec 1

PMID 8971035

Citations 10

Authors

T Vuorinen

R Vainionpaa

R Vanharanta

T Hyypia

Affiliations

Soon will be listed here.

Abstract

Viremia is commonly observed in association with enterovirus infections, and during this phase viruses can be transmitted to secondary target organs in the body. It is not known, however, whether blood cells play a role in the pathogenesis of enterovirus infection supporting virus replication. Our earlier work (T. Vuorinen, R. Vainionpää, H. Kettinen, and T. Hyypiä, Blood 84:823-829, 1994) demonstrated that coxsackievirus B3 is able to replicate in representatives of B- and T-cell lines but not in a monocytic cell line or peripheral blood mononuclear cells, indicating that virus replication may depend on the differentiation and maturation stages of the cells. Therefore, we have broaden our studies and analyzed the susceptibility of granulocyte-macrophage CFU and hematopoietic cell lines with various differentiation and maturation stages to coxsackievirus B3 infection. Virus replication was detected in B- and T-cell lines with no direct correlation to the maturation stage. Granulocyte-macrophage CFU were also able to support virus multiplication.

Citing Articles

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Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors.

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Enterovirus infections of the central nervous system.

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Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie b3 viruses.

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