Immunoreactive Inhibin, Müllerian Inhibitory Substance, and Activin As Biochemical Markers for Juvenile Granulosa Cell Tumors

Ovarian juvenile granulosa cell tumors are a rare cause of sexual precocity. Clinical examination, serum estradiol levels, and pelvic imaging studies have been used traditionally to detect such tumors. Immunoassays for müllerian inhibitory substance and inhibin have recently been noted to provide a more sensitive means of tumor detection in adults. We now describe two girls with this type of tumor in whom serum concentrations of inhibin and müllerian inhibitory substance were used as tumor markers.