Mechanism of Action of Hemolysin III from Bacillus Cereus

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1996 Oct 23

PMID 8962879

Citations 50

Authors

G E Baida

N P Kuzmin

Affiliations

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Abstract

Bacillus cereus hemolysin III activity was tested in crude extracts, from Escherichia coli carrying the hly-III gene. It was concluded that hemolysin III is a pore-forming hemolysin with functional pore diameter of about 3-3.5 nm. Hemolysis occurs in at least three steps: (i) the temperature-dependent binding of the Hly-III monomers to the erythrocyte membrane; (ii) the temperature-dependent formation of the transmembrane oligomeric pore; (iii) the temperature-independent erythrocyte lysis.

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