In Vitro Activity of Quinolones and Other Antimicrobial Agents Against Anaerobic Bacteria

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 1996 Dec 1

PMID 8953101

Citations 11

Authors

C E Nord

Affiliations

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Abstract

The in vitro activities of ciprofloxacin, ofloxacin, sparfloxacin, and DU-6859a against peptostreptococci, Clostridium perfringens, Clostridium difficile, Bacteroides fragilis, Porphyromonas, Prevotella, and Fusobacterium were determined by an agar dilution method. These activities were compared with those of piperacillin/tazobactam, cefoxitin, imipenem, clindamycin, and metronidazole. Imipenem, metronidazole, and DU-6859a were the most active antimicrobial agents that were tested. The in vitro activity of DU-6859a was superior to those of ciprofloxacin, lomefloxacin, ofloxacin, and sparfloxacin.

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