Effects of Sand Fly Vector Saliva on Development of Cutaneous Lesions and the Immune Response to Leishmania Braziliensis in BALB/c Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1996 Dec 1

PMID 8945606

Citations 37

Authors

H C Lima

R G Titus

Affiliations

Soon will be listed here.

Abstract

The saliva of the sand fly vector of leishmaniasis significantly enhanced infection with doses of >10(4) Leishmania braziliensis parasites in BALB/c mice. With a dose of 10(7) L. braziliensis parasites, 60 to 70% of the mice developed lifetime infections. Mice infected with L. braziliensis plus saliva produced two- to threefold more interleukin-4 than did mice infected with L. braziliensis alone. Treatment with a neutralizing anti-interleukin-4 antibody abrogated the effects of the saliva.

Citing Articles

Immune response profiles from humans experimentally exposed to bites.

de Araujo F, Abdeladhim M, Teixeira C, Hummer K, Wilkerson M, Ressner R Front Immunol. 2024; 15:1335307.

PMID: 38633260 PMC: 11021656. DOI: 10.3389/fimmu.2024.1335307.

DNA plasmid coding for Phlebotomus sergenti salivary protein PsSP9, a member of the SP15 family of proteins, protects against Leishmania tropica.

Gholami E, Oliveira F, Taheri T, Seyed N, Gharibzadeh S, Gholami N PLoS Negl Trop Dis. 2019; 13(1):e0007067.

PMID: 30633742 PMC: 6345478. DOI: 10.1371/journal.pntd.0007067.

Immunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection.

Gomes R, Cavalcanti K, Teixeira C, Carvalho A, Mattos P, Cristal J PLoS Negl Trop Dis. 2016; 10(11):e0005078.

PMID: 27812113 PMC: 5094744. DOI: 10.1371/journal.pntd.0005078.

Purinergic signaling and infection by Leishmania: A new approach to evasion of the immune response.

de Figueiredo A, Souza-Testasicca M, Afonso L Biomed J. 2016; 39(4):244-250.

PMID: 27793266 PMC: 6139394. DOI: 10.1016/j.bj.2016.08.004.

Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge.

Resende L, de Oliveira Aguiar-Soares R, Gama-Ker H, Roatt B, Mendonca L, Alves M PLoS One. 2016; 11(8):e0161169.

PMID: 27556586 PMC: 4996460. DOI: 10.1371/journal.pone.0161169.

References

Chakkalath H, Titus R . Leishmania major-parasitized macrophages augment Th2-type T cell activation. J Immunol. 1994; 153(10):4378-87. View

Titus R, Ribeiro J . The role of vector saliva in transmission of arthropod-borne disease. Parasitol Today. 1990; 6(5):157-60. DOI: 10.1016/0169-4758(90)90338-5. View

Theodos C, Shankar A, Glasebrook A, Roeder W, Titus R . The effect of treating with anti-interleukin-1 receptor antibody on the course of experimental murine cutaneous leishmaniasis. Parasite Immunol. 1994; 16(11):571-7. DOI: 10.1111/j.1365-3024.1994.tb00312.x. View

Sadick M, Heinzel F, Holaday B, Pu R, Dawkins R, Locksley R . Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med. 1990; 171(1):115-27. PMC: 2187647. DOI: 10.1084/jem.171.1.115. View

Shankar A, Titus R . T cell and non-T cell compartments can independently determine resistance to Leishmania major. J Exp Med. 1995; 181(3):845-55. PMC: 2191940. DOI: 10.1084/jem.181.3.845. View

OHara J, Paul W . Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature. 1985; 315(6017):333-6. DOI: 10.1038/315333a0. View

Heinzel F, Sadick M, Holaday B, Coffman R, Locksley R . Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989; 169(1):59-72. PMC: 2189187. DOI: 10.1084/jem.169.1.59. View

Puentes S, Silva R, Sacks D, HAMMER C, Joiner K . Serum resistance of metacyclic stage Leishmania major promastigotes is due to release of C5b-9. J Immunol. 1990; 145(12):4311-6. View

Hsieh C, Macatonia S, OGarra A, Murphy K . T cell genetic background determines default T helper phenotype development in vitro. J Exp Med. 1995; 181(2):713-21. PMC: 2191880. DOI: 10.1084/jem.181.2.713. View

10.

Muller I, Louis J . Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites. Eur J Immunol. 1989; 19(5):865-71. DOI: 10.1002/eji.1830190513. View

11.

Boom W, Liebster L, Abbas A, Titus R . Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution. Infect Immun. 1990; 58(12):3863-70. PMC: 313747. DOI: 10.1128/iai.58.12.3863-3870.1990. View

12.

Theodos C, Ribeiro J, Titus R . Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice. Infect Immun. 1991; 59(5):1592-8. PMC: 257889. DOI: 10.1128/iai.59.5.1592-1598.1991. View

13.

Theodos C, Titus R . Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro. Parasite Immunol. 1993; 15(8):481-7. DOI: 10.1111/j.1365-3024.1993.tb00634.x. View

14.

Barral A, Barral-Netto M, Yong E, Brownell C, Twardzik D, Reed S . Transforming growth factor beta as a virulence mechanism for Leishmania braziliensis. Proc Natl Acad Sci U S A. 1993; 90(8):3442-6. PMC: 46316. DOI: 10.1073/pnas.90.8.3442. View

15.

Titus R, Lima G, Engers H, Louis J . Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T cell populations capable of mediating Leishmania major-specific delayed-type hypersensitivity. J Immunol. 1984; 133(3):1594-600. View

16.

Silva R, Hall B, Joiner K, Sacks D . CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. J Immunol. 1989; 143(2):617-22. View

17.

Marchand M, Daoud S, Titus R, Louis J, Boon T . Variants with reduced virulence derived from Leishmania major after mutagen treatment. Parasite Immunol. 1987; 9(1):81-92. DOI: 10.1111/j.1365-3024.1987.tb00490.x. View

18.

Scharton-Kersten T, Afonso L, Wysocka M, Trinchieri G, Scott P . IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol. 1995; 154(10):5320-30. View

19.

Warburg A, Saraiva E, Lanzaro G, Titus R, Neva F . Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. Philos Trans R Soc Lond B Biol Sci. 1994; 345(1312):223-30. DOI: 10.1098/rstb.1994.0097. View

20.

Scott P, Natovitz P, Coffman R, Pearce E, Sher A . Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med. 1988; 168(5):1675-84. PMC: 2189120. DOI: 10.1084/jem.168.5.1675. View