Effect of Lithium Maintenance Treatment on Hypothalamic Pituitary Gonadal Axis in Bipolar Men

Overview

Journal J Psychiatry Neurosci

Specialty Psychiatry

Date 1996 May 1

PMID 8935330

Citations 2

Authors

M Kusalic

F Engelsmann

Affiliations

Soon will be listed here.

Abstract

This was a cross-sectional study assessing short- and long-term effects of lithium (Li) treatment on hormone levels. Levels of testosterone (T), prolactin (PRL), luteinizing hormone (LH), and follicule-stimulating hormone (FSH) were compared. Sixty-one lithium-treated, euthymic, stable, bipolar men were compared with 67 hospital controls and 22 healthy volunteers. Prolactin (P < or = 0.01) and luteinizing hormone (P < or = 0.001) were higher in all patients compared with healthy volunteers. Li-treated patients were evaluated at 22 to 24 mo, 2 to 5 y, and after more than 5 y of Li therapy. At 22 to 24 mo of Li treatment, levels of PRL and LH did not differ from the values of healthy volunteers or of patients treated for longer periods. In addition, the value of T was higher (P < or = 0.003) than in the group treated longer. Levels of T after more than 5 y of treatment, however, did not differ from those of the healthy volunteers.

Citing Articles

Lithium Enhances the GABAergic Synaptic Activities on the Hypothalamic Preoptic Area (hPOA) Neurons.

Rijal S, Jang S, Park S, Han S Int J Mol Sci. 2021; 22(8).

PMID: 33918982 PMC: 8069239. DOI: 10.3390/ijms22083908.

Effect of lithium maintenance therapy on thyroid and parathyroid function.

Kusalic M, Engelsmann F J Psychiatry Neurosci. 1999; 24(3):227-33.

PMID: 10354657 PMC: 1189013.

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