The Development of the Corpus Callosum in Semilobar and Lobar Holoprosencephaly

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 1996 Dec 1

PMID 8929294

Authors

D Rubinstein

V Youngman

J M Hise

M Baganz

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to determine whether and how a true corpus callosum develops in milder cases of holoprosencephaly.

Materials And Methods: The MR scans of seven patients with holoprosencephaly and a callosum-like structure were reviewed. The anatomy of the callosum-like structure and the pericallosal anatomy were evaluated.

Results: Six of the seven cases had a posterior corpus callosum. The seventh case was indeterminate because lack of myelination prevented confirmation that the callosum-like structure consisted only of white matter. In each case the posterior corpus callosum formed posterior to white matter which spanned the interhemispheric fissure beneath a layer of cortical gray matter.

Conclusion: A posterior corpus callosum can develop in holoprosencephaly because the first callosal axons use the white matter of the undivided hemispheres as a bridge to cross the interhemispheric fissure.

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