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Postprandial Serum Bile Acids in Healthy Man. Evidence for Differences in Absorptive Pattern Between Individual Bile Acids

Overview
Journal Gut
Specialty Gastroenterology
Date 1977 Aug 1
PMID 892604
Citations 24
Authors
B Angelin
I Bjorkhem
Affiliations
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Abstract

The serum concentrations of cholic acid (C), chenodeoxycholic acid (CD), and deoxycholic acid (D) before and after a standardised meal were determined in five healthy female subjects using a highly specific and accurate gas chromatographic-mass spectrometric technique. The C level rose significantly 60 minutes after the meal, reached a peak after 90 minutes, and had returned to the original level after 150 minutes. In contrast, the serum concentrations of CD and D displayed a significant rise by 30 minutes, reached a peak after 90 minutes, but had not returned to fasting levels after 150 minutes. The serum bile acid responses after a meal suggest that there is considerable absorption of dihydroxy bile acids in the proximal small intestine in man.

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References
1.
SANDBERG D, SJOEVALL J, SJOEVALL K, Turner D . MEASUREMENT OF HUMAN SERUM BILE ACIDS BY GAS-LIQUID CHROMATOGRAPHY. J Lipid Res. 1965; 6:182-92. View
2.
Holt P . The roles of bile acids during the process of normal fat and cholesterol absorption. Arch Intern Med. 1972; 130(4):574-83. View
3.
Angelin B, Einarsson K, Hellstrom K . Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects. Gut. 1976; 17(6):420-5. PMC: 1411113. DOI: 10.1136/gut.17.6.420. View
4.
Miyazaki H, Ishibashi M, Inoue M, Ito M, Kubodera T . Simultaneous qualitative and quantitative analyses of bile acids by mass chromatography. J Chromatogr. 1974; 99(0):554-65. View
5.
Larusso N, Korman M, Hoffman N, Hofmann A . Dynamics of the enterohepatic circulation of bile acids. Postprandial serum concentrations of conjugates of cholic acid in health, cholecystectomized patients, and patients with bile acid malabsorption. N Engl J Med. 1974; 291(14):689-92. DOI: 10.1056/NEJM197410032911401. View