Papillary Thyroid Carcinoma in Three Siblings with Familial Adenomatous Polyposis

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 1996 Jan 1

PMID 8919339

Citations 3

Authors

S Civitelli

G Tanzini

F Cetta

M Petracci

M C Pacchiarotti

B Civitelli

Affiliations

Soon will be listed here.

Abstract

The authors report three siblings (two sisters and their aunt, aged 20, 22 and 36, respectively) with familial adenomatous polyposis (FAP) and papillary thyroid carcinoma. After diagnosis of FAP, a single, non palpable nodule was revealed in each patient by routine screening ultrasonography of the gland. The diagnosis of papillary carcinoma was made by fine-needle-aspiration biopsy of the nodules and confirmed by histologic examination of surgical specimens. A review of the literature reveals about 40 reports of such an association, that is considered not fortuitous. Nevertheless, in this family the association seems to be a distinctive, clinical feature of the syndrome, affecting three out of five members intensively screened for extracolonic lesions.

Citing Articles

FAP associated thyroid carcinoma in mother and her daughter.

Kameyama K, Takami H Fam Cancer. 2003; 1(2):83-6.

PMID: 14574002 DOI: 10.1023/a:1013848307459.

Familial nonmedullary thyroid neoplasia.

Harach H Endocr Pathol. 2001; 12(2):97-112.

PMID: 11579685 DOI: 10.1385/ep:12:2:097.

Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study.

Soravia C, Sugg S, Berk T, Mitri A, Cheng H, Gallinger S Am J Pathol. 1999; 154(1):127-35.

PMID: 9916927 PMC: 1853451. DOI: 10.1016/S0002-9440(10)65259-5.

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