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How the Brain Keeps the Eyes Still

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Specialty Science
Date 1996 Nov 12
PMID 8917592
Citations 163
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Abstract

The brain can hold the eyes still because it stores a memory of eye position. The brain's memory of horizontal eye position appears to be represented by persistent neural activity in a network known as the neural integrator, which is localized in the brainstem and cerebellum. Existing experimental data are reinterpreted as evidence for an "attractor hypothesis" that the persistent patterns of activity observed in this network form an attractive line of fixed points in its state space. Line attractor dynamics can be produced in linear or nonlinear neural networks by learning mechanisms that precisely tune positive feedback.

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References
1.
Robinson D . A note on the oculomotor pathway. Exp Neurol. 1968; 22(1):130-2. DOI: 10.1016/0014-4886(68)90024-1. View

2.
du Lac S, Lisberger S . Membrane and firing properties of avian medial vestibular nucleus neurons in vitro. J Comp Physiol A. 1995; 176(5):641-51. DOI: 10.1007/BF01021584. View

3.
Keller E, Robinson D . Absence of a stretch reflex in extraocular muscles of the monkey. J Neurophysiol. 1971; 34(5):908-19. DOI: 10.1152/jn.1971.34.5.908. View

4.
Rosen M . A theoretical neural integrator. IEEE Trans Biomed Eng. 1972; 19(5):362-7. DOI: 10.1109/TBME.1972.324139. View

5.
Lopez-Barneo J, Darlot C, Berthoz A, Baker R . Neuronal activity in prepositus nucleus correlated with eye movement in the alert cat. J Neurophysiol. 1982; 47(2):329-52. DOI: 10.1152/jn.1982.47.2.329. View