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Significant Influence of Accompanying Chronic Hepatitis Status on Recurrence of Hepatocellular Carcinoma After Hepatectomy. Result of Multivariate Analysis

Overview
Journal Ann Surg
Specialty General Surgery
Date 1996 Nov 1
PMID 8916872
Citations 36
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Abstract

Objective: The aim of this study was to evaluate the correlation between the histologic status of accompanying chronic hepatitis and the recurrence rate of hepatocellular carcinoma (HCC) after hepatectomy by multivariate analysis.

Summary Background Data: Recent studies have suggested that a considerable number of intrahepatic recurrence of HCC after hepatectomy might be the results of metachronous multicentric hepatocarcinogenesis. The authors hypothesized that the incidence of recurrence due to metachronous multicentric hepatocarcinogenesis would depend on the histologic status of accompanying chronic viral liver disease, which is a main promoter of HCC.

Methods: One hundred ten patients with HCC who underwent curative resection were studied. Histologic status of accompanying chronic hepatitis was classified into the three categories: 1) normal liver or chronic persistent hepatitis (CPH, n = 13), 2) chronic aggressive hepatitis (CAH, n = 50), and 3) liver cirrhosis (LC, n = 47).

Results: The Cox multivariate proportional hazard model showed that the accompanying chronic viral hepatitis status (p = 0.0133), extent of hepatectomy (p = 0.0078), and number of tumors (p = 0.0475) were significantly predictive variables for recurrence-free survival. By the log-rank test, recurrence-free survival rate in patients with CPH was significantly higher than those in patients with CAH (p = 0.0005) and LC (p = 0.0075). Patients with CAH had the lowest recurrence-free survival rate (vs. LC, p = 0.028).

Conclusions: The results of this study indicated the significant influence of histologic activity of hepatitis on recurrence of HCC. This might support the concept of significant contribution of multicentric hepatocarcinogenesis to recurrence of HCC after hepatectomy.

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References
1.
Oda T, Tsuda H, Scarpa A, Sakamoto M, Hirohashi S . Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res. 1992; 52(13):3674-8. View

2.
Sasaki Y, Imaoka S, Masutani S, Ohashi I, Ishikawa O, Koyama H . Influence of coexisting cirrhosis on long-term prognosis after surgery in patients with hepatocellular carcinoma. Surgery. 1992; 112(3):515-21. View

3.
Nagasue N, Kohno H, Chang Y, Taniura H, Yamanoi A, Uchida M . Liver resection for hepatocellular carcinoma. Results of 229 consecutive patients during 11 years. Ann Surg. 1993; 217(4):375-84. PMC: 1242804. DOI: 10.1097/00000658-199304000-00009. View

4.
Ouchi K, Matsubara S, Fukuhara K, Tominaga T, Matsuno S . Recurrence of hepatocellular carcinoma in the liver remnant after hepatic resection. Am J Surg. 1993; 166(3):270-3. DOI: 10.1016/s0002-9610(05)80972-9. View

5.
Derenzini M, Trere D, Oliveri F, David E, Colombatto P, Bonino F . Is high AgNOR quantity in hepatocytes associated with increased risk of hepatocellular carcinoma in chronic liver disease?. J Clin Pathol. 1993; 46(8):727-9. PMC: 501457. DOI: 10.1136/jcp.46.8.727. View