A Unifying Theory of Atherogenesis

Overview

Journal Med Hypotheses

Specialty General Medicine

Date 1996 Oct 1

PMID 8910882

Citations 7

Authors

G D Sloop

Affiliations

Soon will be listed here.

Abstract

The author proposes that all major risk factors, including elevated serum low-density lipoprotein, cause atherosclerosis by increasing viscosity, creating larger areas of decreased blood flow, thereby perpetuating the interaction of atherogenic elements with the endothelium. Low-density lipoprotein causes increased viscosity by fostering erythrocyte aggregation. High-density lipoprotein protects against atherosclerosis by antagonizing erythrocyte aggregation, thereby decreasing viscosity. Implications of this theory are discussed.

Citing Articles

Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen.

Sun J, Han K, Xu M, Li L, Qian J, Li L Front Physiol. 2022; 13:827428.

PMID: 35283762 PMC: 8914209. DOI: 10.3389/fphys.2022.827428.

Impact of velocity gradient in Poiseuille flow on the statistics of coherent radiation scattered by flowing Brownian particles in optical coherence tomography.

Popov I, Weatherbee A, Vitkin A J Biomed Opt. 2019; 24(9):1-7.

PMID: 31562708 PMC: 6997670. DOI: 10.1117/1.JBO.24.9.097001.

Apolipoprotein(a) is the Product of a Pseudogene: Implications for the Pathophysiology of Lipoprotein(a).

Sloop G, Pop G, Weidman J, St Cyr J Cureus. 2018; 10(5):e2715.

PMID: 30079281 PMC: 6067813. DOI: 10.7759/cureus.2715.

Validated formulae for estimation of whole blood viscosity underestimate the influence of erythrocyte aggregation and deformability.

Weidman J, Sloop G, St Cyr J Ther Adv Cardiovasc Dis. 2016; 10(4):271-3.

PMID: 27060185 PMC: 5942630. DOI: 10.1177/1753944716642676.

The clinical significance of whole blood viscosity in (cardio)vascular medicine.

Pop G, Duncker D, Gardien M, Vranckx P, Versluis S, Hasan D Neth Heart J. 2015; 10(12):512-516.

PMID: 25696056 PMC: 2499821.