Contribution of 65-kDa Heat Shock Protein Induced by Gamma and Delta T Cells to Protection Against Toxoplasma Gondii Infection

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 1996 Jan 1

PMID 8902580

Citations 1

Authors

K Himeno

H Hisaeda

Affiliations

Soon will be listed here.

Abstract

Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides synthesized by many cells to preserve cellular functions under a variety of stressful conditions including infections. We have investigated the involvement of 65-kDa HSP (HSP65) in host protection against an intracellular protozoan parasite, Toxoplasma gondii, in mice. Experiments using low and highly virulent strains of Tox. gondii revealed that induction of murine HSP65 on macrophages closely correlates with protection against infection with this protozoan. Furthermore, we clarified that T cells, especially gamma delta T cells, are indispensable for HSP65 expression. A similar relationship between the expression of HSP65 on host macrophages and protective immunity was observed in mice infected with Leishmania major and Trypanosoma cruzi, both of which are obligate intracellular protozoa as is Tox. gondii.

Citing Articles

Role of heat shock proteins in protection from and pathogenesis of infectious diseases.

Zugel U, Kaufmann S Clin Microbiol Rev. 1999; 12(1):19-39.

PMID: 9880473 PMC: 88905. DOI: 10.1128/CMR.12.1.19.

References

Koga T, Debruyn J, Munk M, Schoel B, Kaufmann S . T cells against a bacterial heat shock protein recognize stressed macrophages. Science. 1989; 245(4922):1112-5. DOI: 10.1126/science.2788923. View

Gazzinelli R, Hieny S, Wynn T, Wolf S, Sher A . Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A. 1993; 90(13):6115-9. PMC: 46878. DOI: 10.1073/pnas.90.13.6115. View

Scalise F, Gerli R, Castellucci G, Spinozzi F, Fabietti G, Crupi S . Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis. Immunology. 1992; 76(4):668-70. PMC: 1421574. View

Johnson L . SCID mouse models of acute and relapsing chronic Toxoplasma gondii infections. Infect Immun. 1992; 60(9):3719-24. PMC: 257382. DOI: 10.1128/iai.60.9.3719-3724.1992. View

Kaufmann S, Kabelitz D . Gamma/delta T lymphocytes and heat shock proteins. Curr Top Microbiol Immunol. 1991; 167:191-207. DOI: 10.1007/978-3-642-75875-1_11. View

Yano A, Norose K, Yamashita K, Aosai F, Sugane K, Segawa K . Immune response to Toxoplasma gondii--analysis of suppressor T cells in a patient with symptomatic acute toxoplasmosis. J Parasitol. 1987; 73(5):954-61. View

Forsdyke D . Heat shock proteins defend against intracellular pathogens: a non-immunological basis for self/non-self discrimination?. J Theor Biol. 1985; 115(3):471-3. DOI: 10.1016/s0022-5193(85)80205-8. View

Murray H, Teitelbaum R, Hariprashad J . Response to treatment for an intracellular infection in a T cell-deficient host: toxoplasmosis in nude mice. J Infect Dis. 1993; 167(5):1173-7. DOI: 10.1093/infdis/167.5.1173. View

Haregewoin A, Soman G, Hom R, Finberg R . Human gamma delta+ T cells respond to mycobacterial heat-shock protein. Nature. 1989; 340(6231):309-12. DOI: 10.1038/340309a0. View

10.

Anderton S, van der Zee R, Goodacre J . Inflammation activates self hsp60-specific T cells. Eur J Immunol. 1993; 23(1):33-8. DOI: 10.1002/eji.1830230107. View

11.

Nagasawa H, Oka M, Maeda K, Hisaeda H, Ito Y, GOOD R . Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection. Proc Natl Acad Sci U S A. 1992; 89(7):3155-8. PMC: 48823. DOI: 10.1073/pnas.89.7.3155. View

12.

Cerf-Bensussan N, Malissen B, Briottet C, Vassalli P . Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med. 1991; 173(2):471-81. PMC: 2118788. DOI: 10.1084/jem.173.2.471. View

13.

VanBuskirk A, Crump B, MARGOLIASH E, Pierce S . A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J Exp Med. 1989; 170(6):1799-809. PMC: 2189524. DOI: 10.1084/jem.170.6.1799. View

14.

Polla B, Kantengwa S . Heat shock proteins and inflammation. Curr Top Microbiol Immunol. 1991; 167:93-105. DOI: 10.1007/978-3-642-75875-1_6. View

15.

Lindquist S . The heat-shock response. Annu Rev Biochem. 1986; 55:1151-91. DOI: 10.1146/annurev.bi.55.070186.005443. View

16.

Christmas S . Cytokine production by T lymphocytes bearing the gamma-delta T cell antigen receptor. Chem Immunol. 1992; 53:32-46. View

17.

Van der Ploeg L, Giannini S, Cantor C . Heat shock genes: regulatory role for differentiation in parasitic protozoa. Science. 1985; 228(4706):1443-6. DOI: 10.1126/science.4012301. View

18.

Haas W, Pereira P, Tonegawa S . Gamma/delta cells. Annu Rev Immunol. 1993; 11:637-85. DOI: 10.1146/annurev.iy.11.040193.003225. View

19.

Nagasawa H, Manabe T, Maekawa Y, Oka M, Himeno K . Role of L3T4+ and Lyt-2+ T cell subsets in protective immune responses of mice against infection with a low or high virulent strain of Toxoplasma gondii. Microbiol Immunol. 1991; 35(3):215-22. DOI: 10.1111/j.1348-0421.1991.tb01550.x. View

20.

Hisaeda H, Nagasawa H, Maeda K, Maekawa Y, Ishikawa H, Ito Y . Gamma delta T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii. J Immunol. 1995; 155(1):244-51. View