Design and Evaluation of Two-phase Partition-dissolution Method and Its Use in Evaluating Artemisinin Tablets

Overview

Journal J Pharm Sci

Publisher Elsevier

Specialties Pharmacology
Pharmacy

Date 1996 Oct 1

PMID 8897271

Citations 5

Authors

N T Hoa

R Kinget

Affiliations

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Abstract

A method is described for the assessment of the dissolution behavior of solid dosage forms with a high content of a very water insoluble drug. In this method the dissolved drug is continuously extracted from the aqueous dissolution medium into an organic phase. The reported data on the dissolution of artemisinin show that this method guarantees sink conditions in the aqueous dissolution medium during the total duration of the experiment.

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