Imipenem Therapy of Brain Abscesses

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 1996 Aug 1

PMID 8894574

Citations 4

Authors

V Asensi

J A Carton

J A Maradona

J M Asensi

F Perez

P Redondo

A Lopez

J M Arribas

Affiliations

Soon will be listed here.

Abstract

The efficacy of imipenem versus standard chemotherapy (both in addition to neurosurgery) in the treatment of brain abscess was compared in a retrospective study. Cure was obtained in 52 of 60 (86.7%) patients in the standard group, and in 15 of 15 (including 5 patients with multiple brain abscesses) in the imipenem group. Cure without neurosurgery was observed in 2 of 60 (3.3%) and 3 of 15 (20%) of the cases, respectively (p = 0.08). Levels of imipenem in blood, cerebrospinal fluid, and brain pus were above the minimum inhibitory concentrations of most of the abscess isolates. Side effects of imipenem were rare and tolerance was excellent. Imipenem monotherapy (3-4 g/day) for five weeks seems a reasonable therapeutic choice for treatment of bacterial brain abscesses.

Citing Articles

Brain abscess: Current management.

Alvis Miranda H, Castellar-Leones S, Elzain M, Moscote-Salazar L J Neurosci Rural Pract. 2013; 4(Suppl 1):S67-81.

PMID: 24174804 PMC: 3808066. DOI: 10.4103/0976-3147.116472.

Inflammatory index and treatment of brain abscess.

Oyama H, Kito A, Maki H, Hattori K, Noda T, Wada K Nagoya J Med Sci. 2012; 74(3-4):313-24.

PMID: 23092104 PMC: 4831240.

Brain abscess associated with multidrug-resistant Capnocytophaga ochracea infection.

Wang H, Chen Y, Teng L, Hung C, Chen M, Du S J Clin Microbiol. 2006; 45(2):645-7.

PMID: 17135428 PMC: 1829059. DOI: 10.1128/JCM.01815-06.

Diagnosis and management of brain abscess and subdural empyema.

Bernardini G Curr Neurol Neurosci Rep. 2004; 4(6):448-56.

PMID: 15509445 DOI: 10.1007/s11910-004-0067-8.

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