Neutralization Serotypes of Human Immunodeficiency Virus Type 1 Field Isolates Are Not Predicted by Genetic Subtype. The WHO Network for HIV Isolation and Characterization

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Nov 1

PMID 8892904

Citations 35

Authors

J Weber

E M Fenyo

S Beddows

P Kaleebu

A Bjorndal

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+ polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype-specific neutralization was observed. Most plasma tested were broadly cross-neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.

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