Inhibition of Liver Metastasis of Human Gastric Carcinoma by Angiogenesis Inhibitor TNP-470

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 1996 Sep 1

PMID 8878459

Citations 5

Authors

T Shishido

T Yasoshima

R Denno

N Sato

K Hirata

Affiliations

Soon will be listed here.

Abstract

The anti-tumor and anti-metastatic effects of TNP-470, an angiogenesis inhibitor, and mitomycin C (MMC), a representative anti-neoplastic agent, were investigated using our established liver-metastasizing gastric carcinoma line, AZ-H5c. AZ-H5c was injected into the spleen of nude mice which had been randomly divided into 4 groups; a control group given saline solution, a group receiving 15 mg/kg TNP-470, a group receiving 30 mg/kg TNP-470 and a group receiving 2 mg/kg MMC. TNP-470 was given s.c. on alternate days for 5 weeks from day 10 after intrasplenic injection, and MMC was administered intraperitoneally (i.p.) once a week from day 10 after intrasplenic injection. In the control group, liver metastasis developed in 13 of 16 mice (81%). Liver metastasis developed in 6 of 11 mice (55%) receiving MMC. In contrast, liver metastasis developed in 4 of 8 mice (50%) receiving 15 mg/kg TNP-470, and in 0 of 14 mice (0%) receiving 30 mg/kg TNP-470. However, TNP-470 had no effect on the tumor growth. These results indicate that the angiogenesis inhibitor TNP-470 has a strong inhibitory activity against in vivo liver metastasis of human gastric carcinoma.

Citing Articles

(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis.

Zhu B, Zhan W, Li Z, Wang Z, He Y, Peng J World J Gastroenterol. 2007; 13(8):1162-9.

PMID: 17451194 PMC: 4146988. DOI: 10.3748/wjg.v13.i8.1162.

Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine.

Wang X, Tu L, Wang L, Zhou J J Zhejiang Univ Sci B. 2006; 7(10):837-43.

PMID: 16972327 PMC: 1599809. DOI: 10.1631/jzus.2006.B0837.

Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches.

Poon R, Fan S, Wong J Ann Surg. 2003; 238(1):9-28.

PMID: 12832961 PMC: 1422670. DOI: 10.1097/01.sla.0000075047.47175.35.

Anti-angiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470.

Ishikura H, Kawarada Y, Furuya M, Kondo S, Kato H, Yoshiki T Jpn J Cancer Res. 2001; 92(1):67-73.

PMID: 11173546 PMC: 5926580. DOI: 10.1111/j.1349-7006.2001.tb01049.x.

Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin.

Shishido T, Yasoshima T, Denno R, Mukaiya M, Sato N, Hirata K Jpn J Cancer Res. 1998; 89(9):963-9.

PMID: 9818033 PMC: 5921950. DOI: 10.1111/j.1349-7006.1998.tb00655.x.

References

Kusaka M, Sudo K, Fujita T, Marui S, Itoh F, Ingber D . Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. Biochem Biophys Res Commun. 1991; 174(3):1070-6. DOI: 10.1016/0006-291x(91)91529-l. View

Yasoshima T, Denno R, Kawaguchi S, Sato N, Okada Y, Ura H . Establishment and characterization of human gastric carcinoma lines with high metastatic potential in the liver: changes in integrin expression associated with the ability to metastasize in the liver of nude mice. Jpn J Cancer Res. 1996; 87(2):153-60. PMC: 5921068. DOI: 10.1111/j.1349-7006.1996.tb03153.x. View

Yamaoka M, Yamamoto T, Masaki T, Ikeyama S, Sudo K, Fujita T . Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470). Cancer Res. 1993; 53(18):4262-7. View

Konno H, Tanaka T, Matsuda I, Kanai T, Maruo Y, Nishino N . Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer. Int J Cancer. 1995; 61(2):268-71. DOI: 10.1002/ijc.2910610221. View

Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H . Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature. 1990; 348(6301):555-7. DOI: 10.1038/348555a0. View

Yamaoka M, Yamamoto T, Ikeyama S, Sudo K, Fujita T . Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res. 1993; 53(21):5233-6. View

Folkman J . Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg. 1972; 175(3):409-16. PMC: 1355186. DOI: 10.1097/00000658-197203000-00014. View

Yamamoto T, Sudo K, Fujita T . Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470). Anticancer Res. 1994; 14(1A):1-3. View

Teicher B, Holden S, Dupuis N, Kakeji Y, Ikebe M, Emi Y . Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Res Treat. 1995; 36(2):227-36. DOI: 10.1007/BF00666043. View

10.

Morikawa K, Walker S, Jessup J, Fidler I . In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res. 1988; 48(7):1943-8. View

11.

Folkman J . Tumor angiogenesis. Adv Cancer Res. 1985; 43:175-203. DOI: 10.1016/s0065-230x(08)60946-x. View

12.

Kim K, Li B, Winer J, Armanini M, Gillett N, PHILLIPS H . Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993; 362(6423):841-4. DOI: 10.1038/362841a0. View

13.

Placidi L, Cretton-Scott E, De Sousa G, Rahmani R, Placidi M, Sommadossi J . Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes. Cancer Res. 1995; 55(14):3036-42. View

14.

Iigo M, Nishikata K, Nakajima Y, Araki E . Effects of antitumor agents on subcutaneous implants and hepatic metastases of colon carcinoma 26 in mice. Jpn J Cancer Res. 1992; 83(4):397-401. PMC: 5918823. DOI: 10.1111/j.1349-7006.1992.tb00121.x. View

15.

Tanaka T, Konno H, Matsuda I, Nakamura S, Baba S . Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res. 1995; 55(4):836-9. View

16.

Kusaka M, Sudo K, Matsutani E, Kozai Y, Marui S, Fujita T . Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). Br J Cancer. 1994; 69(2):212-6. PMC: 1968693. DOI: 10.1038/bjc.1994.41. View

17.

Yanase T, Tamura M, Fujita K, Kodama S, Tanaka K . Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res. 1993; 53(11):2566-70. View

18.

Toi M, Yamamoto Y, Imazawa T, Takayanagi T, Akutsu K, Tominaga T . Antitumor effect of the angiogenesis inhibitor agm-1470 and its combination effect with tamoxifen in dmba induced mammary-tumors in rats. Int J Oncol. 2011; 3(3):525-8. DOI: 10.3892/ijo.3.3.525. View