Lazaroids Inhibit Proliferation of Cultured Human Astrocytoma Cells

Overview

Journal J Neurooncol

Publisher Springer

Date 1996 Aug 1

PMID 8858519

Citations 1

Authors

P Arora

Y S Lee

T C Origitano

R D Wurster

Affiliations

Soon will be listed here.

Abstract

Lazaroids (or 21-aminosteroids) are potent lipid peroxidation inhibitors and are more potent antioxidants than steroids which have been shown to suppress tumor proliferation. The effects of two lazaroid compounds (U-75389G and U-83836E) were tested on the proliferation of a human brain astrocytoma cell line U-373MG. Both lazaroids had dose-dependent growth-inhibitory effects on the proliferation of U-373MG. For purposes of comparison, two steroids (methylprednisolone and dexamethasone) and a highly potent antioxidant (alpha-tocopherol) were tested under similar experimental conditions and were found to have antiproliferative effects as well, although at higher dose ranges. As cell growth-inhibitors, lazaroids are more effective than alpha-tocopherol while they are advantageous over glucocorticoids for their actions are devoid of the usual glucocorticoid side-effects.

Citing Articles

Lipid peroxidation and activity of some antioxidant enzymes in patients with glioblastoma and astrocytoma.

Wozniak B, Wozniak A, Kasprzak H, Drewa G, Mila-Kierzenkowska C, Drewa T J Neurooncol. 2006; 81(1):21-6.

PMID: 16773213 DOI: 10.1007/s11060-006-9202-5.

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