Article: Robust method for estimating motor unit firing-pattern statistics

An error-filtered estimation (EFE) algorithm for estimating the mean and standard deviation of a set of time intervals between consecutive motor unit firing times (inter-pulse intervals (IPIs)) is described. As the input IPI data are filtered and only valid IPIs are used to estimate mean and standard deviation values, the EFE algorithm provides accurate estimates even when the data defining the train of motor unit firing times are only partially complete or have several erroneous firing times. The algorithm has been evaluated using both simulated and real motor unit firing time data, and has been found to provide accurate and unbiased mean and standard deviation estimates, even when up to 70% of the IPI data are incorrect.

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References

1.

Englehart K, Parker P . Single motor unit myoelectric signal analysis with nonstationary data. IEEE Trans Biomed Eng. 1994; 41(2):168-80. DOI: 10.1109/10.284928. View

2.

Clamann H . Statistical analysis of motor unit firing patterns in a human skeletal muscle. Biophys J. 1969; 9(10):1233-51. PMC: 1367516. DOI: 10.1016/S0006-3495(69)86448-9. View

3.

McGill K, Cummins K, Dorfman L . Automatic decomposition of the clinical electromyogram. IEEE Trans Biomed Eng. 1985; 32(7):470-7. DOI: 10.1109/TBME.1985.325562. View

4.

De Luca C, LeFever R, McCue M, Xenakis A . Behaviour of human motor units in different muscles during linearly varying contractions. J Physiol. 1982; 329:113-28. PMC: 1224770. DOI: 10.1113/jphysiol.1982.sp014293. View

5.

Rosenfalck A, Andreassen S . Impaired regulation of force and firing pattern of single motor units in patients with spasticity. J Neurol Neurosurg Psychiatry. 1980; 43(10):907-16. PMC: 490711. DOI: 10.1136/jnnp.43.10.907. View

6.

Reiners K, Herdmann J, Freund H . Altered mechanisms of muscular force generation in lower motor neuron disease. Muscle Nerve. 1989; 12(8):647-59. DOI: 10.1002/mus.880120806. View

7.

Stashuk D, Qu Y . Adaptive motor unit action potential clustering using shape and temporal information. Med Biol Eng Comput. 1996; 34(1):41-9. DOI: 10.1007/BF02637021. View

8.

De Luca C . Physiology and mathematics of myoelectric signals. IEEE Trans Biomed Eng. 1979; 26(6):313-25. DOI: 10.1109/tbme.1979.326534. View

9.

De Luca C, LeFever R, McCue M, Xenakis A . Control scheme governing concurrently active human motor units during voluntary contractions. J Physiol. 1982; 329:129-42. PMC: 1224771. DOI: 10.1113/jphysiol.1982.sp014294. View

10.

LeFever R, De Luca C . A procedure for decomposing the myoelectric signal into its constituent action potentials--Part I: Technique, theory, and implementation. IEEE Trans Biomed Eng. 1982; 29(3):149-57. DOI: 10.1109/tbme.1982.324881. View

11.

Andreassen S, Rosenfalck A . Regulation of the firing pattern of single motor units. J Neurol Neurosurg Psychiatry. 1980; 43(10):897-906. PMC: 490710. DOI: 10.1136/jnnp.43.10.897. View

12.

Kukulka C, Clamann H . Comparison of the recruitment and discharge properties of motor units in human brachial biceps and adductor pollicis during isometric contractions. Brain Res. 1981; 219(1):45-55. DOI: 10.1016/0006-8993(81)90266-3. View

Robust Method for Estimating Motor Unit Firing-pattern Statistics