Circulating Adhesion Molecules in the Critically Ill: a Comparison Between Trauma and Sepsis Patients

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 1996 Feb 1

PMID 8857119

Citations 17

Authors

J Boldt

M Muller

D Kuhn

L C Linke

G Hempelmann

Affiliations

Soon will be listed here.

Abstract

Objective: The time course of circulating adhesion molecules was monitored in traumatized and sepsis patients.

Design: Prospective, descriptive.

Setting: A surgical intensive care unit of a university hospital.

Patients: A total of 30 consecutive critically ill patients suffering either from trauma (n = 15) or postoperative sepsis (n = 15).

Interventions: All patients were on continuous analgo-sedation and mechanical ventilation.

Measurements And Results: From arterial blood samples, plasma levels of soluble adhesion molecules [endothelial leukocyte adhesion molecules (sELAM-1), intercellular adhesion molecule-1 (sICAM-1)], and vascular cell adhesion molecule-1 (sVCAM-1) were measured on the day of admission (trauma patients) or on the day of diagnosis of sepsis (= baseline values), and during the following 5 days. In the trauma group, sELAM-1 (57.9 +/- 11.0 ng/ml) and sVCAM-1 (698 +/- 93 ng/ml) were within normal ranges at baseline, whereas they were markedly elevated in the sepsis group (sELAM-1: 340 +/- 95 ng/ml; sVCAM-1; 1,042 +/- 449 ng/ml). In the sepsis patients, sELAM-1 significantly decreased and sVCAM-1 increased, but remained almost unchanged in the trauma patients. Non-survivors showed markedly elevated plasma levels of sELAM-1 and sVCAM-1. sICAM-1 was elevated in both groups at baseline and was higher in the sepsis group (1,266 +/- 261 ng/ml) than in the trauma group. In the septic patients, sICAM-1 increased further (2,022 +/- 609 ng/ml) and remained unchanged in the trauma group. All non-survivors showed sICAM-1 plasma levels of > 800 ng/ml.

Conclusions: Endothelial damage may result in multiple-organ dysfunction syndrome. Adhesion molecules are considered to be a cornerstone in this process. Trauma patients showed lower plasma levels of circulating adhesion molecules than did sepsis patients indicating more pronounced (inflammatory related) endothelial activation or damage in sepsis. Therapeutic modulation of circulating adhesion molecules may be of benefit to the patients outcome and therefore warrants further study.

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References

Redl H, Dinges H, Buurman W, van der Linden C, Pober J, COTRAN R . Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. Am J Pathol. 1991; 139(2):461-6. PMC: 1886066. View

Murray J, Matthay M, Luce J, Flick M . An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988; 138(3):720-3. DOI: 10.1164/ajrccm/138.3.720. View

Osborn L . Leukocyte adhesion to endothelium in inflammation. Cell. 1990; 62(1):3-6. DOI: 10.1016/0092-8674(90)90230-c. View

Verrier E, Shen I . Potential role of neutrophil anti-adhesion therapy in myocardial stunning, myocardial infarction, and organ dysfunction after cardiopulmonary bypass. J Card Surg. 1993; 8(2 Suppl):309-12. DOI: 10.1111/j.1540-8191.1993.tb01330.x. View

Lawrence M, Springer T . Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell. 1991; 65(5):859-73. DOI: 10.1016/0092-8674(91)90393-d. View

Rothlein R, Mainolfi E, Czajkowski M, Marlin S . A form of circulating ICAM-1 in human serum. J Immunol. 1991; 147(11):3788-93. View

Fowler A, Fisher B, Centor R, Carchman R . Development of the adult respiratory distress syndrome: progressive alteration of neutrophil chemotactic and secretory processes. Am J Pathol. 1984; 116(3):427-35. PMC: 1900478. View

Gearing A, Newman W . Circulating adhesion molecules in disease. Immunol Today. 1993; 14(10):506-12. DOI: 10.1016/0167-5699(93)90267-O. View

Williams T, Hellewell P . Endothelial cell biology. Adhesion molecules involved in the microvascular inflammatory response. Am Rev Respir Dis. 1992; 146(5 Pt 2):S45-50. DOI: 10.1164/ajrccm/146.5_Pt_2.S45. View

10.

Stoolman L . Adhesion molecules involved in leukocyte recruitment and lymphocyte recirculation. Chest. 1993; 103(2 Suppl):79S-86S. DOI: 10.1378/chest.103.2_supplement.79s. View

11.

Tschaikowsky K, Sittl R, Braun G, Hering W, RUGHEIMER E . Increased fMet-Leu-Phe receptor expression and altered superoxide production of neutrophil granulocytes in septic and posttraumatic patients. Clin Investig. 1993; 72(1):18-25. DOI: 10.1007/BF00231111. View

12.

Palluy O, Morliere L, Gris J, Bonne C, Modat G . Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radic Biol Med. 1992; 13(1):21-30. DOI: 10.1016/0891-5849(92)90161-9. View

13.

Hammer D, Apte S . Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion. Biophys J. 1992; 63(1):35-57. PMC: 1262123. DOI: 10.1016/S0006-3495(92)81577-1. View

14.

Yamazaki M, Asakura H, Sato T, Tsugawa Y, Matsumura M, Kawamura Y . Changes in plasma levels of thrombomodulin during haemodialysis. Blood Coagul Fibrinolysis. 1992; 3(1):113-7. DOI: 10.1097/00001721-199202000-00017. View

15.

Engler R, Dahlgren M, MORRIS D, Peterson M, Schmid-Schonbein G . Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol. 1986; 251(2 Pt 2):H314-23. DOI: 10.1152/ajpheart.1986.251.2.H314. View

16.

Cowley H, Heney D, Gearing A, Hemingway I, Webster N . Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study. Crit Care Med. 1994; 22(4):651-7. DOI: 10.1097/00003246-199404000-00022. View

17.

Ma X, Tsao P, Lefer A . Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J Clin Invest. 1991; 88(4):1237-43. PMC: 295592. DOI: 10.1172/JCI115427. View

18.

Spertini O, Kansas G, Munro J, Griffin J, Tedder T . Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature. 1991; 349(6311):691-4. DOI: 10.1038/349691a0. View

19.

Elices M, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler M . VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990; 60(4):577-84. DOI: 10.1016/0092-8674(90)90661-w. View

20.

Pelletier R, Ohye R, VanBuskirk A, Sedmak D, Kincade P, Ferguson R . Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo. J Immunol. 1992; 149(7):2473-81. View