Effects of Freund's Complete Adjuvant on the Diurnal Rhythms of Neuroendocrine Processes and Ornithine Decarboxylase Activity in Various Tissues of Male Rats

Overview

Journal Experientia

Specialty Science

Date 1996 Sep 15

PMID 8841519

Citations 1

Authors

M Neidhart

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the effects of Freund's complete adjuvant (FCA) on the diurnal rhythms of hormonal parameters in serum and ornithine decarboxylase (ODC) activity in various tissues of male rats. On days 1-2 after FCA, increase of ODC activity (used to evaluate the level of activation) was observed in the hypothalamus, pituitary gland, adrenal medulla, adrenal cortex, liver and lymphoid tissues, while the ODC activity in the kidney was reduced. This was accompanied by an increase in serum corticosterone. On days 3-4 after FCA, ODC activity remained elevated in the pituitary gland, liver and lymphoid tissues, while the ODC activity in the testes and pancreas was reduced; kidney ODC activity returned to baseline. This was associated with increased serum levels of prolactin (Prl) and luteinizing hormone, but decreased growth hormone, testosterone and insulin. The increase in ODC activity in the thymus, as well as the reduced ODC activity in the testes and kidney, can be obtained with paraffin. Furthermore, bromocryptine microcapsules (CBLA) reduced the FCA-induced increase of ODC activity in the pituitary gland, liver and lymphoid tissues (days 3-4) but did not affect the changes in other tissues. The increase in ODC activity in the pituitary gland, liver and lymphoid tissues is specific for FCA. A role for Prl in the induction of ODC in liver and lymphoid tissues is suggested by the fact that CBLA suppresses this enhancement.

Citing Articles

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction.

Esquifino A, Cano P, Jimenez-Ortega V, Fernandez-Mateos P, Cardinali D Endocrine. 2007; 32(1):1-19.

PMID: 17992597 DOI: 10.1007/s12020-007-9009-y.

References

Cincotta A, Knisely T, Landry R, Miers W, Gutierrez P, Esperanza P . The immunoregulatory effects of prolactin in mice are time of day dependent. Endocrinology. 1995; 136(5):2163-71. DOI: 10.1210/endo.136.5.7720666. View

. Prolactin stimulates transcription of growth-related genes in Nb2 T lymphoma cells. Mol Cell Endocrinol. 1990; 68(1):21-8. DOI: 10.1016/0303-7207(90)90165-5. View

Strumpfer A, Hsiao J, Peng T, Richards J . Effect of lithium chloride on ornithine decarboxylase activity in rat adrenal. Can J Physiol Pharmacol. 1992; 70(9):1293-6. DOI: 10.1139/y92-180. View

Badamchian M, Spangelo B, Damavandy T, MacLeod R, Goldstein A . Complete amino acid sequence analysis of a peptide isolated from the thymus that enhances release of growth hormone and prolactin. Endocrinology. 1991; 128(3):1580-8. DOI: 10.1210/endo-128-3-1580. View

Neidhart M, Larson D . Freund's complete adjuvant induces ornithine decarboxylase activity in the central nervous system of male rats and triggers the release of pituitary hormones. J Neuroimmunol. 1990; 26(2):97-105. DOI: 10.1016/0165-5728(90)90080-7. View

Crowe P, Buckley A, Zorn N, Rui H . Prolactin activates protein kinase C and stimulates growth-related gene expression in rat liver. Mol Cell Endocrinol. 1991; 79(1-3):29-35. DOI: 10.1016/0303-7207(91)90092-7. View

Arkins S, Dantzer R, Kelley K . Somatolactogens, somatomedins, and immunity. J Dairy Sci. 1993; 76(8):2437-50. DOI: 10.3168/jds.S0022-0302(93)77579-7. View

Bartlett R, Schleyerbach R . Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity--I. Disease modifying action on adjuvant arthritis of the rat. Int J Immunopharmacol. 1985; 7(1):7-18. DOI: 10.1016/0192-0561(85)90003-7. View

Berczi I, Nagy E . A possible role of prolactin in adjuvant arthritis. Arthritis Rheum. 1982; 25(5):591-4. DOI: 10.1002/art.1780250517. View

10.

Gonzalez S, Suescun M, Rulli S, Estivariz F, Calandra R . Modulation of ornithine decarboxylase activity by prolactin in seminal vesicles of the rat. Int J Androl. 1994; 17(3):143-8. DOI: 10.1111/j.1365-2605.1994.tb01234.x. View

11.

Scott I, Poso H, Akerman K, Andersson L . Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes. Eur J Immunol. 1985; 15(8):783-7. DOI: 10.1002/eji.1830150808. View

12.

Murphy W, Rui H, Longo D . Effects of growth hormone and prolactin immune development and function. Life Sci. 1995; 57(1):1-14. DOI: 10.1016/0024-3205(95)00237-z. View

13.

Rillema J . Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Proc Soc Exp Biol Med. 1985; 178(3):490-4. DOI: 10.3181/00379727-178-rc2. View

14.

VAN ARMAN C . Pathway to adjuvant arthritis. Fed Proc. 1976; 35(13):2442-6. View

15.

Neidhart M, Fluckiger E . Hyperprolactinaemia in hypophysectomized or intact male rats and the development of adjuvant arthritis. Immunology. 1992; 77(3):449-55. PMC: 1421702. View

16.

Russell D . Ornithine decarboxylase: a key regulatory enzyme in normal and neoplastic growth. Drug Metab Rev. 1985; 16(1-2):1-88. DOI: 10.3109/03602538508991430. View

17.

Langlois A, Morisset J . Effects of feeding, fasting, and caerulein treatment on ornithine decarboxylase in rat pancreas. Pancreas. 1991; 6(5):534-41. DOI: 10.1097/00006676-199109000-00006. View

18.

Neidhart M . Elevated serum prolactin or elevated prolactin/cortisol ratio are associated with autoimmune processes in systemic lupus erythematosus and other connective tissue diseases. J Rheumatol. 1996; 23(3):476-81. View

19.

Wilder R . Neuroendocrine-immune system interactions and autoimmunity. Annu Rev Immunol. 1995; 13:307-38. DOI: 10.1146/annurev.iy.13.040195.001515. View

20.

Brelje T, Parsons J, Sorenson R . Regulation of islet beta-cell proliferation by prolactin in rat islets. Diabetes. 1994; 43(2):263-73. DOI: 10.2337/diab.43.2.263. View