Long-term Depression in Hippocampus

Overview

Journal Annu Rev Neurosci

Specialty Neurology

Date 1996 Jan 1

PMID 8833450

Citations 176

Authors

M F Bear

W C Abraham

Affiliations

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Abstract

Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic input. Homosynaptic LTD can occur at synapses that are activated, normally at low frequencies. Here we discuss the mechanisms of LTD and their possible relevance to hippocampal function.

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