Fatty Acids Selectively Inhibit Eukaryotic DNA Polymerase Activities in Vitro

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1996 Sep 11

PMID 8809118

Citations 32

Authors

Y Mizushina

N Tanaka

H Yagi

T Kurosawa

M Onoue

H Seto

T Horie

N Aoyagi

M Yamaoka

A Matsukage

S Yoshida

K Sakaguchi

Affiliations

Soon will be listed here.

Abstract

The in vitro relationship between eukaryotic DNA polymerases and fatty acids was investigated. Some fatty acids strongly inhibited the activities of DNA polymerase alpha and/or beta in vitro. The kinetics of inhibition by linoleic acid showed that DNA polymerase alpha was non-competitively inhibited with respect to the DNA template and substrate (dTTP), while DNA polymerase beta was inhibited competitively with both DNA and substrate.

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