The Lid That Shapes the Pot: Structure and Function of the Chaperonin GroES
Overview
Biotechnology
Cell Biology
Molecular Biology
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The structure of GroES reveals a potential for instability at odds with the idea of a fixed ring whose only flexible regions are at the outer edges. The importance of GroES in chaperoned protein folding is highlighted by evidence that folding substrates are transiently enclosed under the GroES cap.
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