» Articles » PMID: 8805046

The Genetic Contribution to Stature

Overview
Journal Horm Res
Specialty Endocrinology
Date 1996 Jan 1
PMID 8805046
Citations 20
Authors
Affiliations
Soon will be listed here.
Abstract

A strong resemblance exists between the height of family members, and the extent of this similarity increases as the family relationship becomes closer. This suggests that there is a genetic basis to adult height. The genetic basis of height is particularly apparent in monozygotic twins who have been reared apart. Although it is difficult to separate completely the genetic and environmental components that influence growth, there does appear to be a strong genetic influence on final height achieved and the timing of key stages in the growth pathway.

Citing Articles

Polygenic height prediction for the Han Chinese in Taiwan.

Chang C, Chou C, Raben T, Chen S, Jong Y, Wu J NPJ Genom Med. 2025; 10(1):7.

PMID: 39910149 PMC: 11799370. DOI: 10.1038/s41525-025-00468-6.


Human height: a model common complex trait.

Conery M, Grant S Ann Hum Biol. 2023; 50(1):258-266.

PMID: 37343163 PMC: 10368389. DOI: 10.1080/03014460.2023.2215546.


Clinical phenotype of ASD-associated haploinsufficiency.

Earl R, Turner T, Mefford H, Hudac C, Gerdts J, Eichler E Mol Autism. 2017; 8:54.

PMID: 29034068 PMC: 5629761. DOI: 10.1186/s13229-017-0173-5.


Evidence of inbreeding depression on human height.

Mcquillan R, Eklund N, Pirastu N, Kuningas M, McEvoy B, Esko T PLoS Genet. 2012; 8(7):e1002655.

PMID: 22829771 PMC: 3400549. DOI: 10.1371/journal.pgen.1002655.


Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.

Lee J, Essers J, Kugathasan S, Escher J, Lettre G, Butler J Ann Hum Genet. 2010; 74(6):489-97.

PMID: 20846217 PMC: 2955808. DOI: 10.1111/j.1469-1809.2010.00606.x.