Autoimmunity in Dilated Cardiomyopathy and the Major Histocompatibility Complex

Overview

Journal Int J Cardiol

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 1996 May 1

PMID 8803674

Citations 9

Authors

C J Limas

Affiliations

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Abstract

Autoimmune mechanisms are likely to participate in the pathogenesis of a subgroup of dilated cardiomyopathy. These mechanisms involve the elaboration of autoantibodies against cardiac proteins as well as abnormal lymphocyte regulation. The presence of autoantibodies against beta-adrenoceptors correlates with the human leukocyte antigen (HLA)-DR4/1 phenotypes and specific T-cell receptor haplotypes. In addition, histidine at position 36 of the HLA-DQ beta 1 gene is associated with the presence of clinically manifest dilated cardiomyopathy. Components of the major histocompatibility complex (MHC) may thus serve as markers for the propensity to develop immune-mediated myocardial damage.

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