Inhibition of Vagally Induced Gastric Contractions by Sympathetic Stimulation, Neuropeptide Y and Galanin

The effects on vagally-induced gastric contractions of local electrical stimulation of the gastric sympathetic nerves were investigated in anaesthetised cats. Sympathetic stimulation caused an inhibition of vagally mediated gastric contractions which survived beta-adrenoceptor blockade and could not be mimicked by the alpha-adrenoceptor agonist phenylephrine. We therefore concluded that the inhibition was not predominantly dependent upon activation of alpha or beta adrenoceptors, although some effect attributable to noradrenaline could not be entirely excluded. In an attempt to determine the mechanism of this phenomenon, we administered exogenous neuropeptide Y (NPY) and galanin (GAL), both of which are known to occur as cotransmitters in some sympathetic nerves in the cat. Both NPY and GAL were able to mimic the effect of sympathetic stimulation on vagally-induced gastric contractions but their effects were variable.