Transcriptional Activation Function is Not Required for Stimulation of DNA Replication by Bovine Papillomavirus Type 1 E2

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1996 Oct 1

PMID 8794380

Citations 25

Authors

M J Grossel

F Sverdrup

D E Breiding

E J Androphy

Affiliations

Soon will be listed here.

Abstract

Bovine papillomavirus type 1 replication was previously shown to require both the E1 initiator protein and the E2 transactivator protein. We show here that E1, in the absence of E2, is sufficient for low-level bovine papillomavirus type 1 DNA replication in C-33A cells. In addition, studies of genetically isolated E2 point mutants demonstrate that enhancement of replication by E2 does not require its transcriptional activation function. The uncoupling of the E2 functions suggests that stimulation of transcription and replication by enhancer proteins occurs via divergent mechanisms.

Citing Articles

Acetylation of E2 by P300 Mediates Topoisomerase Entry at the Papillomavirus Replicon.

Thomas Y, Androphy E J Virol. 2019; 93(7).

PMID: 30651357 PMC: 6430547. DOI: 10.1128/JVI.02224-18.

Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication.

Kanginakudru S, DeSmet M, Thomas Y, Morgan I, Androphy E Virology. 2015; 478:129-35.

PMID: 25666521 PMC: 4361275. DOI: 10.1016/j.virol.2015.01.011.

Targeting human papillomavirus genome replication for antiviral drug discovery.

Archambault J, Melendy T Antivir Ther. 2013; 18(3):271-83.

PMID: 23615820 PMC: 4658057. DOI: 10.3851/IMP2612.

Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1.

Gagnon D, Senechal H, DAbramo C, Alvarez J, McBride A, Archambault J Virology. 2013; 439(2):132-9.

PMID: 23490049 PMC: 4654618. DOI: 10.1016/j.virol.2013.02.012.

Acetylation of conserved lysines in bovine papillomavirus E2 by p300.

Quinlan E, Culleton S, Wu S, Chiang C, Androphy E J Virol. 2012; 87(3):1497-507.

PMID: 23152516 PMC: 3554136. DOI: 10.1128/JVI.02771-12.

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