Cdk Inhibitors in Development and Cancer

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 1996 Feb 1

PMID 8791491

Citations 97

Authors

J W Harper

S J Elledge

Affiliations

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Abstract

Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycle regulation have uncovered two families of proteins that bind and inhibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between the pathways of development and tumorigenesis.

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