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Fibrinolytic Activity in the Walls of Cerebral Saccular Aneurysms

Overview
Journal Acta Neurochir (Wien)
Specialty Neurosurgery
Date 1977 Jan 1
PMID 878925
Citations 5
Authors
O HASSLER
H Fodstad
Affiliations
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Abstract

The fibrinolytic activity of 28 cerebral saccular aneurysms from 24 patients and of controls consisting of 10 cerebral arteries has been studied by Todd's autography technique. An increased activity was seen in the minute adventitial vessels and in the endothelium in ruptured cerebral saccular aneurysms, but the aneurysms showed somewhat less activity than the surrounding arteries. Seven patients with subarachnoid haemorrhage had the same increase in fibrinolytic activity in the aneurysmal wall despite antifibrinolytic therapy ante mortem. This finding has been discussed.

Citing Articles

Determination of tranexamic acid (AMCA) and fibrin/fibrinogen degradation products in cerebrospinal fluid after aneurysmal subarachnoid haemorrhage.

Fodstad H, Pilbrant A, Schannong M, Stromberg S Acta Neurochir (Wien). 1981; 58(1-2):1-13.

PMID: 7282453 DOI: 10.1007/BF01401679.

Coagulation and fibrinolysis in blood and cerebrospinal fluid after aneurysmal subarachnoid haemorrhage: effect of tranexamic acid (AMCA).

Fodstad H, Nilsson I Acta Neurochir (Wien). 1981; 56(1-2):25-38.

PMID: 7195642 DOI: 10.1007/BF01400969.

Antifibrinolytic treatment in subarachnoid haemorrhage: present state.

Fodstad H Acta Neurochir (Wien). 1982; 63(1-4):233-44.

PMID: 7048863 DOI: 10.1007/BF01728877.

Spontaneous thrombosis of ruptured intracranial aneurysms during treatment with tranexamic acid (AMCA). Report of three cases.

Fodstad H, LILIEQUIST B Acta Neurochir (Wien). 1979; 49(3-4):129-44.

PMID: 517175 DOI: 10.1007/BF01808955.

Antifibrinolytic therapy of subarachnoid hemorrhage by intrathecal administration of p-aminomethylbenzoic acid.

HEIDRICH R, Markwardt F, Endler S, Hindersin P J Neurol. 1978; 219(1):83-5.

PMID: 81287 DOI: 10.1007/BF00313371.

References
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