Structure of a Molluscan Cardioexcitatory Neuropeptide

Overview

Journal Science

Specialty Science

Date 1977 Aug 12

PMID 877582

Citations 159

Authors

D A Price

M J Greenberg

Affiliations

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Abstract

A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide amide Phe-Met-Arg-Phe-NH2. Its structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis. This neuropeptide is active at about 10(-8)M when assayed on molluscan muscle.

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