The D2 Dopamine Receptor Gene As a Determinant of Reward Deficiency Syndrome

Overview

Journal J R Soc Med

Specialty General Medicine

Date 1996 Jul 1

PMID 8774539

Citations 175

Authors

K Blum

P J Sheridan

R C Wood

E R Braverman

T J Chen

J G Cull

D E Comings

Affiliations

Soon will be listed here.

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

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