Systemic Corticosteroids in the Phenytoin Hypersensitivity Syndrome

Overview

Journal Br J Dermatol

Publisher Oxford University Press

Specialty Dermatology

Date 1996 Jun 1

PMID 8763435

Citations 12

Authors

S Chopra

N J Levell

G Cowley

J J Gilkes

Affiliations

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Abstract

A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests. The use of systemic corticosteroids in this condition is not established. We report the resolution of all the features of PHS with systemic corticosteroids and recurrence on withdrawal, and further remission on reinstitution of systemic corticosteroids.

Citing Articles

Case Series on DRESS: An Unpredictable Adverse Drug Reaction.

Fatima M, Azimi S, Ashwini S, Radhakrishna M Mediterr J Rheumatol. 2023; 34(2):245-251.

PMID: 37654627 PMC: 10466359. DOI: 10.31138/mjr.34.2.245.

Leflunomide Induced Atypical DRESS: A Case Report and Literature Review.

Fatima M, Azimi S, Ashwini S, Radhakrishna M Mediterr J Rheumatol. 2023; 34(1):91-96.

PMID: 37223589 PMC: 10201105. DOI: 10.31138/mjr.34.1.91.

Systemic Versus Topical Corticosteroids in the Treatment of DRESS: A Retrospective Cohort Study Followed by a Meta-Analysis.

Lian B, Ha J, Sultana R, Chan L, Choo K, Yeo Y Am J Clin Dermatol. 2023; 24(4):637-647.

PMID: 37133714 DOI: 10.1007/s40257-023-00776-6.

Characterizing DRESS syndrome recurrence: a systematic review.

Sharma A, Shwe S, Ravi V, Miller M, Mesinkovska N, Rojek N Arch Dermatol Res. 2021; 314(8):721-728.

PMID: 34505944 DOI: 10.1007/s00403-021-02274-3.

DRESS syndrome: an important differential for eosinophilia with systemic organ dysfunction.

Mukit W, Cooper R, Moudgil H, Ahmad N BMJ Case Rep. 2020; 13(5).

PMID: 32398248 PMC: 7222870. DOI: 10.1136/bcr-2020-234251.