Nitric Oxide Synthase Levels in Obese Zucker Rats

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1996 May 10

PMID 8762001

Citations 6

Authors

J E Morley

M B Mattammal

Affiliations

Soon will be listed here.

Abstract

Nitric oxide has been demonstrated to play a role in the modulation of food intake. The Zucker fatty rat is an autosomal recessive genetic model of obesity. We measured nitric oxide synthase (NOS) in the hypothalamus and fundus of the stomach in Zucker (fa/fa) rats and their lean littermate controls (fa/?). NOS activity was decreased in both the hypothalamus and the fundus of the Zucker (fa/fa) rats compared to the littermate controls.

Citing Articles

The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats.

Merdzo I, Rutkai I, Tokes T, Sure V, Katakam P, Busija D Am J Physiol Heart Circ Physiol. 2016; 310(7):H830-8.

PMID: 26873973 PMC: 4867359. DOI: 10.1152/ajpheart.00964.2015.

Increased neuronal nitric oxide synthase dimerisation is involved in rat and human pancreatic beta cell hyperactivity in obesity.

Mezghenna K, Pomies P, Chalancon A, Castex F, Leroy J, Niclauss N Diabetologia. 2011; 54(11):2856-66.

PMID: 21847584 DOI: 10.1007/s00125-011-2264-8.

Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation.

do Carmo J, Bassi M, da Silva A, Hall J Hypertension. 2011; 57(3):428-34.

PMID: 21263126 PMC: 3073740. DOI: 10.1161/HYPERTENSIONAHA.110.163931.

Increase of NADPH-diaphorase expression in hypothalamus of stat4 knockout mice.

Hong M, Song J, Yun D, Cho J, Chung J Korean J Physiol Pharmacol. 2009; 13(5):337-41.

PMID: 19915694 PMC: 2776892. DOI: 10.4196/kjpp.2009.13.5.337.

Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.

Tiwari S, Sharma N, Gill P, Igarashi P, Kahn C, Wade J Proc Natl Acad Sci U S A. 2008; 105(17):6469-74.

PMID: 18424559 PMC: 2359822. DOI: 10.1073/pnas.0711283105.