Role of Gamma Interferon in a Neonatal Mouse Model of Group B Streptococcal Disease

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1996 Aug 1

PMID 8757817

Citations 16

Authors

V Cusumano

G Mancuso

F Genovese

D Delfino

C Beninati

E Losi

G Teti

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to assess the role of gamma interferon (IFN-gamma) in a neonatal mouse model of group B streptococcal (GBS) sepsis. IFN-gamma was produced by spleen cells at 24, 48, and 72 h after GBS challenge. Treatment with anti-IFN-gamma at 6 h before challenge totally abrogated the IFN-gamma response but did not affect survival. Subcutaneous administration of recombinant IFN-gamma (2,500 IU per pup) at 18 h after challenge resulted in increased survival time and reduced blood colony counts at 48 and 72 h. In vitro preincubation of neonatal whole blood with IFN-gamma before the addition of GBS resulted in significant restriction of bacterial growth. These data indicate that administration of recombinant IFN-gamma can partially restore impaired host defenses against GBS in neonatal mice. This cytokine may be useful for the treatment of neonatal infections.

Citing Articles

Neurodevelopmental impairment associated with neonatal invasive group B disease: Are animal models on track in understanding the mechanisms at play?.

Khan K Brain Behav Immun Health. 2024; 40:100831.

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Dysregulated monocyte-derived macrophage response to Group B in newborns.

Ravi D, Ntinopoulou E, Guetta N, Weier M, Vogel V, Spellerberg B Front Immunol. 2023; 14:1268804.

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Siglec-5 is an inhibitory immune checkpoint molecule for human T cells.

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Bacterial and Host Determinants of Group B Streptococcal Infection of the Neonate and Infant.

Furuta A, Brokaw A, Manuel G, Dacanay M, Marcell L, Seepersaud R Front Microbiol. 2022; 13:820365.

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Chen J, Yang S, Li W, Yu W, Fan Z, Wang M J Microbiol Biotechnol. 2021; 31(5):667-675.

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