Hyponatraemia and Cerebral Convulsion Due to Short Term DDAVP Therapy for Control of Enuresis Nocturna

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1996 Jan 1

PMID 8750810

Citations 3

Authors

M Schwab

D Wenzel

H Ruder

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Desmopressin (DDAVP) is frequently used in the treatment of primary isolated enuresis nocturna if other approaches have failed. We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis.

Conclusion: Although adverse reactions in DDAVP (e.g. hyponatraemia) are rare, it should not be considered as the first choice treatment of enuresis nocturna and only be used with caution.

Citing Articles

Comparative tolerability of drug treatment for nocturnal enuresis in children.

Muller D, Roehr C, Eggert P Drug Saf. 2004; 27(10):717-27.

PMID: 15350155 DOI: 10.2165/00002018-200427100-00002.

Hyponatraemic convulsion secondary to desmopressin treatment for primary enuresis.

Apakama D, Bleetman A J Accid Emerg Med. 1999; 16(3):229-30.

PMID: 10353057 PMC: 1343345. DOI: 10.1136/emj.16.3.229.

Drug-induced syndrome of inappropriate antidiuretic hormone secretion. Causes, diagnosis and management.

Chan T Drugs Aging. 1997; 11(1):27-44.

PMID: 9237039 DOI: 10.2165/00002512-199711010-00004.

References

Miller K, Atkin B, Moody M . Drug therapy for nocturnal enuresis. Current treatment recommendations. Drugs. 1992; 44(1):47-56. DOI: 10.2165/00003495-199244010-00004. View

Knudsen U, Rittig S, Norgaard J, Lundemose J, Pedersen E, Djurhuus J . Long-term treatment of nocturnal enuresis with desmopressin. A follow-up study. Urol Res. 1991; 19(4):237-40. DOI: 10.1007/BF00305302. View

Miller K, Klauber G . Desmopressin acetate in children with severe primary nocturnal enuresis. Clin Ther. 1990; 12(4):357-66. View

Vavra I, Machova A, Holecek V, CORT J, Zaoral M, Sorm F . Effect of a synthetic analogue of vasopressin in animals and in patients with diabetes insipidus. Lancet. 1968; 1(7549):948-52. DOI: 10.1016/s0140-6736(68)90904-5. View

Kohler M, Harris A . Pharmacokinetics and haematological effects of desmopressin. Eur J Clin Pharmacol. 1988; 35(3):281-5. DOI: 10.1007/BF00558266. View

Sukhai R . Enuresis nocturna: long term use and safety aspects of minrin (desmopressin) spray. Regul Pept. 1993; 45(1-2):309-10. DOI: 10.1016/0167-0115(93)90226-x. View

Aladjem M, Wohl R, Boichis H, Orda S, Lotan D, Freedman S . Desmopressin in nocturnal enuresis. Arch Dis Child. 1982; 57(2):137-40. PMC: 1627511. DOI: 10.1136/adc.57.2.137. View

Bamford M, Cruickshank G . Dangers of intranasal desmopressin for nocturnal enuresis. J R Coll Gen Pract. 1989; 39(325):345-6. PMC: 1711970. View

Moffatt M, Harlos S, Kirshen A, Burd L . Desmopressin acetate and nocturnal enuresis: how much do we know?. Pediatrics. 1993; 92(3):420-5. View

10.

Wille S . Comparison of desmopressin and enuresis alarm for nocturnal enuresis. Arch Dis Child. 1986; 61(1):30-3. PMC: 1777552. DOI: 10.1136/adc.61.1.30. View

11.

Alon U . Nocturnal enuresis. Pediatr Nephrol. 1995; 9(3):94-103. View

12.

JANKNEGT R, Smans A . Treatment with desmopressin in severe nocturnal enuresis in childhood. Br J Urol. 1990; 66(5):535-7. DOI: 10.1111/j.1464-410x.1990.tb15005.x. View

13.

Terho P . Desmopressin in nocturnal enuresis. J Urol. 1991; 145(4):818-20. DOI: 10.1016/s0022-5347(17)38461-6. View

14.

Simmonds E, Mahony M, Little J . Convulsion and coma after intranasal desmopressin in cystic fibrosis. BMJ. 1988; 297(6663):1614. PMC: 1835280. DOI: 10.1136/bmj.297.6663.1614. View

15.

Fjellestad-Paulsen A, Wille S, Harris A . Comparison of intranasal and oral desmopressin for nocturnal enuresis. Arch Dis Child. 1987; 62(7):674-7. PMC: 1779260. DOI: 10.1136/adc.62.7.674. View

16.

Rew D, Rundle J . Assessment of the safety of regular DDAVP therapy in primary nocturnal enuresis. Br J Urol. 1989; 63(4):352-3. DOI: 10.1111/j.1464-410x.1989.tb05215.x. View

17.

Klauber G . Clinical efficacy and safety of desmopressin in the treatment of nocturnal enuresis. J Pediatr. 1989; 114(4 Pt 2):719-22. DOI: 10.1016/s0022-3476(89)80887-x. View

18.

Marild S, Jodal U, Jonasson G, Mangelus L, Oden A, PERSSON N . Reference values for renal concentrating capacity in children by the desmopressin test. Pediatr Nephrol. 1992; 6(3):254-7. DOI: 10.1007/BF00878361. View