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The Effect of Sera from Patients with Connective Tissue Diseases on Red Cell Binding and Phagocytosis by Monocytes

Overview
Journal Immunology
Specialty Allergy & Immunology
Date 1977 Jul 1
PMID 873570
Citations 4
Authors
A Temple
G LOEWI
Affiliations
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Abstract

The uptake by human blood monocytes of sheep erythrocytes treated with rabbit anti-sheep antibody with or without mouse complement was assessed by a radioactive method to discover whether immune complexes would inhibit this reaction. It was found that sera from SLE patients inhibited uptake whereas normal sera enhanced. Some rheumatoid sera and rheumatoid joint fluids inhibited uptake whereas sera from juvenile rheumatoid patients did not.

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Evidence for intrinsic cellular defects of 'complement' receptor-mediated phagocytosis in patients with systemic lupus erythematosus (SLE).

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Depressed exocytosis by rheumatoid neutrophils in vitro.

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In vitro studies on the Fc-receptor function of mononuclear phagocytes in rheumatoid arthritis: relation between the Fc-receptor blockade and the concanavalin A-binding capacity of autologous immunoglobulin G.

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