Action of Some Natural Polypeptides on the Longitudinal Muscle of the Guinea Pig Ileum

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1977 Jun 1

PMID 872882

Citations 9

Authors

J Szeli

E Molina

L Zappia

G Bertaccini

Affiliations

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Abstract

The structure--activity relationship of some natural tachykinins was investigated in the longitudinal muscle of the guinea pig ileum. The order of potency was eledoisin greater than uperolein greater than substance P greater than phyllomedusin greater than physalaemin. This ratio of activity is different from that observed in other experimental conditions, and in different in vivo or in vitro preparations; it is suggested that the N-terminal part of the molecule of the tachykinins plays a role in determining the degree of potency of these compounds.

Citing Articles

Effect of substitution of glycine by D- or L-alanine on the activity of the C-terminal hexapeptide analogue of substance P on isolated guinea-pig ileum.

Lipkowski A, DRABAREK S, Majewski T, Konecka A, Sadowski B Experientia. 1981; 37(5):499-500.

PMID: 7250323 DOI: 10.1007/BF01986161.

Innervation of the muscularis mucosae of canine proximal colon.

Angel F, Go V, Szurszewski J J Physiol. 1984; 357:93-108.

PMID: 6210358 PMC: 1193249. DOI: 10.1113/jphysiol.1984.sp015491.

Substance P can contract the longitudinal muscle of the guinea-pig small intestine by releasing intracellular calcium.

Holzer P, Lippe I Br J Pharmacol. 1984; 82(1):259-67.

PMID: 6203591 PMC: 1987250. DOI: 10.1111/j.1476-5381.1984.tb16466.x.

Antidiuretic activities of substance P and its analogs.

Ukai M, Nagase T, Hirohashi M, Yanaihara N Experientia. 1981; 37(5):521-3.

PMID: 6166497 DOI: 10.1007/BF01986174.

Effect of substance P and its natural analogues on gastric emptying of the conscious rat.

Bertaccini G, de Castiglione R, Scarpignato C Br J Pharmacol. 1981; 72(2):221-3.

PMID: 6163494 PMC: 2071498. DOI: 10.1111/j.1476-5381.1981.tb09116.x.