A Gene-rich Cluster Between the CD4 and Triosephosphate Isomerase Genes at Human Chromosome 12p13

Overview

Journal Genome Res

Specialty Genetics

Date 1996 Apr 1

PMID 8723724

Citations 29

Authors

M A Ansari-Lari

D M Muzny

J Lu

F Lu

C E Lilley

S Spanos

T Malley

R A Gibbs

Affiliations

Soon will be listed here.

Abstract

The genomic sequence of the human CD4 gene and its neighboring region, located at chromosome 12p13, was generated using the large-scale shotgun sequencing strategy. A total of 117 kb of genomic sequence and approximately 11 kb of cDNA sequence were obtained. Six genes, including CD4, triosephosphate isomerase, B3 subunit of G proteins (GNB3), and ubiquitin isopeptidase T (ISOT), with known functions, and two new genes with unknown functions were identified. Using a battery of strategies, the exon/intron boundaries, splice variants, and tissue expression patterns of the genes were determined. Various computer software was utilized for analyses of the DNA and amino acid sequences. The results of the analyses and sequence-based strategies for gene identification are discussed.

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