Processing of Pre-ribosomal RNA in Saccharomyces Cerevisiae

Overview

Journal Yeast

Publisher Wiley

Specialty Microbiology

Date 1995 Dec 1

PMID 8720068

Citations 112

Authors

J Venema

D Tollervey

Affiliations

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Abstract

Post-transcriptional processing of precursor-ribosomal RNA comprises a complex pathway of endonucleolytic cleavages, exonucleolytic digestion and covalent modifications. The general order of the various processing steps is well conserved in eukaryotic cells, but the underlying mechanisms are largely unknown. Recent analysis of pre-rRNA processing, mainly in the yeast Saccharomyces cerevisiae, has significantly improved our understanding of this important cellular activity. Here we will review the data that have led to our current picture of yeast pre-rRNA processing.

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