Is Dopamine a Neurohormone of the Adrenal Medulla? Studies with Morphine Stimulation

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1977 Mar 14

PMID 870830

Citations 3

Authors

S R Snider

C Miller

A L PRASAD

V Jackson

S Fahn

Affiliations

Soon will be listed here.

Abstract

Dopamine (da) concentrations in rat adrenals, plasma and brain were variably elevated 1 h after a large parenteral dose of morphine. In adrenals, unlabelled DA increased 2-fold and labelled DA, synthesized from 3H-tyrosine, increased more than 4-fold. The increases could be prevented by inhibition of DA-synthesizing enzymes and spinal cord transection, respectively. Labelled DA in plasma increased 2.7-fold after morphine in intact rats but did not increase in those with spinal cord transection. It is concluded that: (1) morphine stimulates the adrenal by increasing nerve impulse flow, (2) increased nerve impulse flow increases DA synthesis and levels, and (3) the increased DA levels result in increased release of DA into the bloodstream.

Citing Articles

Ultrastructural changes in adrenaline- and SGC-cells after morphine coincide with alterations of adrenaline and dopamine levels.

Harless S, Klein R Cell Tissue Res. 1984; 236(1):53-65.

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The effects of acute and chronic administration of morphine on the turnover of brain and adrenal catecholamines in rats.

Guaza C, Torrellas A, Borrell S, Borrell J Psychopharmacology (Berl). 1980; 68(1):43-9.

PMID: 6104838 DOI: 10.1007/BF00426648.

Appearance of tyrosine hydroxylase, aromatic amino-acid decarboxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase during the ontogenesis of the adrenal medulla: an immunohistochemical study in the rat.

Verhofstad A, Hokfelt T, Goldstein M, Steinbusch H, Joosten H Cell Tissue Res. 1979; 200(1):1-13.

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