Chlamydial Cervicitis and Urethritis: Single Dose Treatment Compared with Doxycycline for Seven Days in Community Based Practises

Overview

Journal Genitourin Med

Specialty Infectious Diseases

Date 1996 Apr 1

PMID 8698374

Citations 10

Authors

E M Thorpe Jr

W E Stamm

E W Hook 3rd

S A Gall

R B Jones

K Henry

G Whitworth

R B Johnson

Affiliations

Soon will be listed here.

Abstract

Study Goal: To compare the efficacy and safety of single 1 g oral azithromycin with doxycycline, 100 mg twice daily for seven days for treatment of uncomplicated urogenital chlamydial infection.

Study Design: Randomised, unblinded, comparative trial, involving 597 patients demonstrating clinical evidence of genital chlamydia and a positive non-culture assay for Chlamydia trachomatis.

Results: Among the azithromycin- and doxycycline-treated patients 61% and 60%, respectively, were asymptomatic within one week after the first dose. At two weeks, these figures increased to 86% and 83%, respectively. Bacteriological eradication, based on a negative assay, occurred in 338 (97%) of 347 azithromycin-treated patients and 161 (99%) of 163 doxycycline-treated patients.

Conclusion: Treatment of uncomplicated chlamydial cervicitis and urethritis with single 1 g oral azithromycin is equivalent to standard therapy with doxycycline. Drug-related adverse events were approximately twice as common as previously reported for both drugs.

Citing Articles

Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis.

Mohammadzadeh F, Dolatian M, Jorjani M, Afrakhteh M, Alavi Majd H, Abdi F Int J Reprod Biomed. 2019; 17(9):603-620.

PMID: 31646255 PMC: 6804326. DOI: 10.18502/ijrm.v17i9.5093.

Antibiotics for treating urogenital Chlamydia trachomatis infection in men and non-pregnant women.

Paez-Canro C, Alzate J, Gonzalez L, Rubio-Romero J, Lethaby A, Gaitan H Cochrane Database Syst Rev. 2019; 1:CD010871.

PMID: 30682211 PMC: 6353232. DOI: 10.1002/14651858.CD010871.pub2.

A Population-Based Study to Compare Treatment Outcomes Among Women With Urogenital Chlamydial Infection in Washington State, 1992 to 2015.

Khosropour C, Bell T, Hughes J, Manhart L, Golden M Sex Transm Dis. 2018; 45(5):319-324.

PMID: 29465681 PMC: 5895502. DOI: 10.1097/OLQ.0000000000000764.

Enrofloxacin and macrolides alone or in combination with rifampicin as antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection.

Prohl A, Lohr M, Ostermann C, Liebler-Tenorio E, Berndt A, Schroedl W PLoS One. 2015; 10(3):e0119736.

PMID: 25768665 PMC: 4358964. DOI: 10.1371/journal.pone.0119736.

The efficacy of oral azithromycin in clearing ocular chlamydia: mathematical modeling from a community-randomized trachoma trial.

Liu F, Porco T, Mkocha H, Munoz B, Ray K, Bailey R Epidemics. 2014; 6:10-7.

PMID: 24593917 PMC: 4420489. DOI: 10.1016/j.epidem.2013.12.001.

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