Making Sense of the Combined Effect of Interleukin-2 and Interleukin-4 on Lymphocytes Using a Mathematical Model

Overview

Journal Bull Math Biol

Publisher Springer

Specialties Biology
Public Health

Date 1996 May 1

PMID 8688839

Citations 5

Authors

B F Morel

M A Burke

J Kalagnanam

S A McCarthy

D J Tweardy

P A Morel

Affiliations

Soon will be listed here.

Abstract

The cytokines are the information superhighway of the immune system. They are an important component of the integrated behavior of the system. In order to be able to have a good understanding of the immune system, we must be able to model the effect of cytokines and their combined effect. This work is a step in that direction. We study the combined effect of two cytokines: interleukin-2 (IL-2) and interleukin-4 (IL-4) on some cells of the immune system. Interleukin-2 and interleukin-4 are important growth and differentiation factors for B and T cells. Interleukin-4 antagonizes the effect of interleukin-2 on B cells and some T cells while it synergizes with interleukin-2 on other T cells. We build a mathematical model of the interaction of both cytokines on T and B cells as a building block toward a model of the Th1/Th2 cross-regulation. The response of a given cell to the combination of interleukin-2 and interleukin-4 is shown to involve competing dynamical effects which can lead to either antagonistic or synergistic combined effect.

Citing Articles

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery.

Tarca A, Fitzgerald W, Chaemsaithong P, Xu Z, Hassan S, Grivel J Am J Reprod Immunol. 2017; 78(3).

PMID: 28585708 PMC: 5575567. DOI: 10.1111/aji.12686.

Demystifying the cytokine network: Mathematical models point the way.

Morel P, Lee R, Faeder J Cytokine. 2016; 98:115-123.

PMID: 27919524 PMC: 5457394. DOI: 10.1016/j.cyto.2016.11.013.

Modeling the T cell immune response: a fascinating challenge.

Morel P, Faeder J, Hawse W, Miskov-Zivanov N J Pharmacokinet Pharmacodyn. 2014; 41(5):401-13.

PMID: 25155903 PMC: 4210366. DOI: 10.1007/s10928-014-9376-y.

Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper T Cell Line.

Comfort K, Haugh J Cell Mol Bioeng. 2013; 1(2-3).

PMID: 24255693 PMC: 3830900. DOI: 10.1007/s12195-008-0015-9.

New insights into mathematical modeling of the immune system.

Morel P, Taasan S, Morel B, Kirschner D, Flynn J Immunol Res. 2007; 36(1-3):157-65.

PMID: 17337776 DOI: 10.1385/IR:36:1:157.

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