Isolation of Inhibitors of TPA-induced Mouse Ear Edema from Hoelen, Poria Cocos

Overview

Journal Chem Pharm Bull (Tokyo)

Specialties Chemistry
Pharmacology

Date 1996 Apr 1

PMID 8681415

Citations 12

Authors

H Nukaya

H Yamashiro

H Fukazawa

H Ishida

K Tsuji

Affiliations

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Abstract

Triterpene carboxylic acids were isolated from the methanol extract of Hoelen, Poria cocos, and found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema. Their chemical structures were identified as 3 beta,-16 alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid, 16 alpha-hydroxydehydropachymic acid, 16 alpha-hydroxytrametenolic acid and dehydrotumulosic acid.

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