Enhanced Expression of PAI-1 in Visceral Fat: Possible Contributor to Vascular Disease in Obesity

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 1996 Jul 1

PMID 8673927

Citations 178

Authors

I Shimomura

T Funahashi

M Takahashi

K Maeda

K Kotani

T Nakamura

S Yamashita

M Miura

Y Fukuda

K Takemura

K Tokunaga

Y Matsuzawa

Affiliations

Soon will be listed here.

Abstract

The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor-1 (PAI-1) levels was investigated in humans and animals. Plasma PAI-1 levels were closely correlated with visceral fat area but not with subcutaneous fat area in human subjects. PAI-1 mRNA was detected in both types of fat tissue in obese rats but increased only in visceral fat during the development of obesity. These data suggest that an enhanced expression of the PAI-1 gene in visceral fat may increase plasma levels and may have a role in the development of vascular disease in visceral obesity.

Citing Articles

Elevated levels of PAI-1 precede the occurrence of type 2 diabetes mellitus.

Hernestal-Boman J, Ohman T, Jansson J, Lind M, Rolandsson O, Bergdahl I Diabetol Metab Syndr. 2025; 17(1):61.

PMID: 39966987 PMC: 11834294. DOI: 10.1186/s13098-025-01629-4.

Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer.

Miracle C, McCallister C, Egleton R, Salisbury T Biochem Biophys Res Commun. 2024; 733:150437.

PMID: 39074412 PMC: 11455618. DOI: 10.1016/j.bbrc.2024.150437.

Kaempferol ameliorates metabolic syndrome by inhibiting inflammation and oxidative stress in high-fat diet-induced obese mice.

Shin S, Kwon E Nutr Res Pract. 2024; 18(3):325-344.

PMID: 38854471 PMC: 11156765. DOI: 10.4162/nrp.2024.18.3.325.

Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review).

Varra F, Varras M, Varra V, Theodosis-Nobelos P Mol Med Rep. 2024; 29(6).

PMID: 38606791 PMC: 11025031. DOI: 10.3892/mmr.2024.13219.

Association between Metabolic Score for Visceral Fat and the risk of hypertension in different ethnic groups: a prospective cohort study in Southwest China.

Zhang F, Wang Y, Zhou J, Yu L, Wang Z, Liu T Front Endocrinol (Lausanne). 2024; 15:1302387.

PMID: 38562413 PMC: 10982387. DOI: 10.3389/fendo.2024.1302387.