Inflammatory Bronchopulmonary Response of Preterm Infants with Microbial Colonisation of the Airways at Birth

Overview

Journal Arch Dis Child Fetal Neonatal Ed

Specialties Gynecology & Obstetrics
Pediatrics

Date 1996 Jan 1

PMID 8653437

Citations 16

Authors

P Groneck

C P Speer

Affiliations

Soon will be listed here.

Abstract

The inflammatory indicators in the tracheobronchial aspirate (TA) of 81 ventilated preterm infants with microbial colonisation of the airways and in non-colonised neonates were analysed on the first day of life. TA was assessed for chemotactic activity, neutrophil cell count, and concentrations of leukotriene B4, C5a, interleukin-1, interleukin-8, elastase-alpha 1-proteinase inhibitor, free elastase and albumin. Concentrations of mediators were related to concentrations of the secretory component of IgA. The infants' gestational age was mean (SD) 27.9 (2.0) weeks, birthweight 945 (179) g. In 12 infants (15%) microbial colonisation of the airways was present (Ureaplasma urealyticum n = 7; bacteria n = 5). Compared with non-colonised neonates (n = 69), chemotactic activity, neutrophil count, and concentrations of interleukin-1, leukotriene B4 and elastase-alpha 1-proteinase inhibitor were significantly higher in the colonised group. The difference was most pronounced for IL-1 concentrations, both with and without correction for secretory component. There was also a trend towards increased concentrations of interleukin-8 in the latter group. There were no differences for concentrations of C5a and albumin in the TA of both groups. It is concluded that airway colonisation with U urealyticum or bacteria at birth is associated with a clinically relevant bronchopulmonary inflammatory response. Increased concentrations of interleukin-1 in TA on the first day of life may be a marker of perinatal colonisation of the airways.

Citing Articles

Clinical Characteristics and Current Treatment Modality of Preterm Infants with spp. Infection.

Zhang Z, Wang J, Chen W, Xu L Children (Basel). 2024; 11(10).

PMID: 39457166 PMC: 11505890. DOI: 10.3390/children11101202.

Ureaplasma-Driven Neuroinflammation in Neonates: Assembling the Puzzle Pieces.

Silwedel C, Speer C, Hartel C, Glaser K Neonatology. 2020; 117(6):665-672.

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Perinatal Exposure Is Associated With Increased Risk of Late Onset Sepsis and Imbalanced Inflammation in Preterm Infants and May Add to Lung Injury.

Glaser K, Gradzka-Luczewska A, Szymankiewicz-Breborowicz M, Kawczynska-Leda N, Henrich B, Waaga-Gasser A Front Cell Infect Microbiol. 2019; 9:68.

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Novel insights into neuroinflammation: bacterial lipopolysaccharide, tumor necrosis factor α, and Ureaplasma species differentially modulate atypical chemokine receptor 3 responses in human brain microvascular endothelial cells.

Silwedel C, Speer C, Haarmann A, Fehrholz M, Claus H, Buttmann M J Neuroinflammation. 2018; 15(1):156.

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Species Differentially Modulate Pro- and Anti-Inflammatory Cytokine Responses in Newborn and Adult Human Monocytes Pushing the State Toward Pro-Inflammation.

Glaser K, Silwedel C, Fehrholz M, Waaga-Gasser A, Henrich B, Claus H Front Cell Infect Microbiol. 2017; 7:484.

PMID: 29234642 PMC: 5712342. DOI: 10.3389/fcimb.2017.00484.

References

Wilmott R, Kassab J, Kilian P, Benjamin W, Douglas S, Wood R . Increased levels of interleukin-1 in bronchoalveolar washings from children with bacterial pulmonary infections. Am Rev Respir Dis. 1990; 142(2):365-8. DOI: 10.1164/ajrccm/142.2.365. View

Webber S, Wilkinson A, Lindsell D, Hope P, Dobson S, Isaacs D . Neonatal pneumonia. Arch Dis Child. 1990; 65(2):207-11. PMC: 1792235. DOI: 10.1136/adc.65.2.207. View

Speer C, Robertson B, Curstedt T, Halliday H, Compagnone D, Gefeller O . Randomized European multicenter trial of surfactant replacement therapy for severe neonatal respiratory distress syndrome: single versus multiple doses of Curosurf. Pediatrics. 1992; 89(1):13-20. View

Ozaki T, Hayashi H, Tani K, OGUSHI F, Yasuoka S, Ogura T . Neutrophil chemotactic factors in the respiratory tract of patients with chronic airway diseases or idiopathic pulmonary fibrosis. Am Rev Respir Dis. 1992; 145(1):85-91. DOI: 10.1164/ajrccm/145.1.85. View

Watts C, Fanaroff A, Bruce M . Elevation of fibronectin levels in lung secretions of infants with respiratory distress syndrome and development of bronchopulmonary dysplasia. J Pediatr. 1992; 120(4 Pt 1):614-20. DOI: 10.1016/s0022-3476(05)82492-8. View

Grigg J, Barber A, Silverman M . Increased levels of bronchoalveolar lavage fluid interleukin-6 in preterm ventilated infants after prolonged rupture of membranes. Am Rev Respir Dis. 1992; 145(4 Pt 1):782-6. DOI: 10.1164/ajrccm/145.4_Pt_1.782. View

Rodriguez J, Miller C, Deforge L, Kelty L, Shanley C, Bartlett R . Local production of interleukin-8 is associated with nosocomial pneumonia. J Trauma. 1992; 33(1):74-81; discussion 81-2. DOI: 10.1097/00005373-199207000-00015. View

Tegtmeyer F, Maacks S, Wood W, Wiebicke W . Elastase alpha 1-proteinase inhibitor and lactoferrin concentrations in endotracheal aspirates of ventilated newborns. Pediatr Pulmonol. 1992; 13(2):90-4. DOI: 10.1002/ppul.1950130206. View

Speer C, Ruess D, Harms K, Herting E, Gefeller O . Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome. Pediatrics. 1993; 91(4):794-9. View

10.

Groneck P, Reuss D, Speer C . Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. J Pediatr. 1993; 122(6):938-44. DOI: 10.1016/s0022-3476(09)90024-5. View

11.

Grigg J, Arnon S, Chase A, Silverman M . Inflammatory cells in the lungs of premature infants on the first day of life: perinatal risk factors and origin of cells. Arch Dis Child. 1993; 69(1 Spec No):40-3. PMC: 1029396. DOI: 10.1136/adc.69.1_spec_no.40. View

12.

Payne N, Steinberg S, Ackerman P, Chrenka B, Sane S, Anderson K . New prospective studies of the association of Ureaplasma urealyticum colonization and chronic lung disease. Clin Infect Dis. 1993; 17 Suppl 1:S117-21. DOI: 10.1093/clinids/17.supplement_1.s117. View

13.

Stancombe B, Walsh W, Derdak S, Dixon P, Hensley D . Induction of human neonatal pulmonary fibroblast cytokines by hyperoxia and Ureaplasma urealyticum. Clin Infect Dis. 1993; 17 Suppl 1:S154-7. DOI: 10.1093/clinids/17.supplement_1.s154. View

14.

Chollet-Martin S, Montravers P, Gibert C, Elbim C, Desmonts J, Fagon J . High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infect Immun. 1993; 61(11):4553-9. PMC: 281204. DOI: 10.1128/iai.61.11.4553-4559.1993. View

15.

Fujimura M, Kitajima H, Nakayama M . Increased leukocyte elastase of the tracheal aspirate at birth and neonatal pulmonary emphysema. Pediatrics. 1993; 92(4):564-9. View

16.

Deforge L, Preston A, Takeuchi E, Kenney J, Boxer L, Remick D . Regulation of interleukin 8 gene expression by oxidant stress. J Biol Chem. 1993; 268(34):25568-76. View

17.

Standiford T, Arenberg D, Danforth J, Kunkel S, VanOtteren G, Strieter R . Lipoteichoic acid induces secretion of interleukin-8 from human blood monocytes: a cellular and molecular analysis. Infect Immun. 1994; 62(1):119-25. PMC: 186076. DOI: 10.1128/iai.62.1.119-125.1994. View

18.

Massion P, Inoue H, Grunberger D, Jorens P, Housset B, Pittet J . Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro. J Clin Invest. 1994; 93(1):26-32. PMC: 293717. DOI: 10.1172/JCI116954. View

19.

Groneck P, Oppermann M, Eiffert H, Speer C . Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics. 1994; 93(5):712-8. View

20.

Kotecha S, Chan B, Azam N, Silverman M, Shaw R . Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 1995; 72(2):F90-6. PMC: 2528395. DOI: 10.1136/fn.72.2.f90. View