A Locus on Chromosome 7 Determines Myocardial Cell Necrosis and Calcification (dystrophic Cardiac Calcinosis) in Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 May 28

PMID 8643601

Citations 25

Authors

B T Ivandic

J H Qiao

D Machleder

F Liao

T A Drake

A J Lusis

Affiliations

Soon will be listed here.

Abstract

Dystrophic cardiac calcinosis, an age-related cardiomyopathy that occurs among certain inbred strains of mice, involves myocardial injury, necrosis, and calcification. Using a complete linkage map approach and quantitative trait locus analysis, we sought to identify genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains. We identified a single major locus, designated Dyscalc, located on proximal chromosome 7 in a region syntenic with human chromosomes 19q13 and 11p15. The statistical significance of Dyscalc (logarithm of odds score 14.6) was tested by analysis of permuted trait data. Analysis of BxH recombinant inbred strains confirmed the mapping position. The inheritance pattern indicated that this locus influences susceptibility of cells both to enter necrosis and to subsequently undergo calcification.

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