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GS28, a 28-kilodalton Golgi SNARE That Participates in ER-Golgi Transport

Overview
Journal Science
Specialty Science
Date 1996 May 24
PMID 8638159
Citations 50
Authors
V N Subramaniam
F Peter
R Philp
S H Wong
W Hong
Affiliations
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Abstract

Little is known about the integral membrane proteins that participate in the early secretory pathway of mammalian cells. The complementary DNA encoding a 28-kilodalton protein (p28) of the cis-Golgi was cloned and sequenced. The protein was predicted to contain a central coiled-coil domain with a carboxyl-terminal membrane anchor. An in vitro assay for endoplasmic reticulum-Golgi transport was used to show that p28 participates in the docking and fusion stage of this transport event. Biochemical studies established that p28 is a core component of the Golgi SNAP receptor (SNARE) complex.

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