Vascular Endothelial Growth Factor B, a Novel Growth Factor for Endothelial Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1996 Mar 19

PMID 8637916

Citations 142

Authors

B Olofsson

K Pajusola

A Kaipainen

G von Euler

V Joukov

O Saksela

A Orpana

R F Pettersson

K Alitalo

U Eriksson

Affiliations

Soon will be listed here.

Abstract

We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.

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