Cerebrospinal Fluid Amine Metabolites After Combined Amitriptyline-triiodothyronine Treatment of Depressed Women

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1977 Apr 20

PMID 862653

Citations 4

Authors

C M Banki

Affiliations

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Abstract

Levels of 5-hydroxyindoleacetic acid and homovanillic acid were measured in cerebrospinal fluid from 33 depressed women with no clinical response to amitriptyline, before and after combination treatment with triiodothyronine. Although the latter showed significant clinical improvement, changes in CSF amine metabolites did not differ significantly from a control group of 16 therapy-resistant depressed women receiving higher doses of amitriptyline. Possible explanations for the mechanism of action of triiodothyronine are discussed.

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References

Wilson I, Prange Jr A, McCLANE T, Rabon A, LIPTON M . Thyroid-hormone enhancement of imipramine in nonretarded depressions. N Engl J Med. 1970; 282(19):1063-7. DOI: 10.1056/NEJM197005072821903. View

RAMSDEN E . Cyclic A.M.P. in depression and mania. Lancet. 1970; 1(7663):108. DOI: 10.1016/s0140-6736(70)92689-9. View

Breulet M, Bourdouxhe S, Parent M, Legros J, Bobon J . [Clinical and neuro-endocrinological study of trh in melancholia]. Acta Psychiatr Belg. 1974; 74(3):254-77. View

Glowinski J, Axelrod J . INHIBITION OF UPTAKE OF TRITIATED-NORADRENALINE IN THE INTACT RAT BRAIN BY IMIPRAMINE AND STRUCTURALLY RELATED COMPOUNDS. Nature. 1964; 204:1318-9. DOI: 10.1038/2041318a0. View

Ogura C, Okuma T, Uchida Y, Imai S, Yogi H . Combined thyroid (triiodothyronine)-tricyclic antidepressant treatment in depressive states. Folia Psychiatr Neurol Jpn. 1974; 28(3):179-86. DOI: 10.1111/j.1440-1819.1974.tb02300.x. View

ABDULLA Y, Hamadah K . 3',5' cyclic adenosine monophosphate in depression and mania. Lancet. 1970; 1(7643):378-81. DOI: 10.1016/s0140-6736(70)91514-x. View

Sjostrom R, ROOS B . 5-Hydroxyindolacetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis. Eur J Clin Pharmacol. 1972; 4(3):170-6. DOI: 10.1007/BF00561141. View

Paul M, Ditzion B, PAUK G, Janowsky D . Urinary adenosine 3',5'-monophosphate excretion in affective disorders. Am J Psychiatry. 1970; 126(10):1493-7. DOI: 10.1176/ajp.126.10.1493. View

Banki C . [The use of triiodothyronine in the treatment of depression]. Orv Hetil. 1975; 116(43):2543-6. View

10.

Coppen A, Prange Jr A, Whybrow P, Noguera R . Abnormalities of indoleamines in affective disorders. Arch Gen Psychiatry. 1972; 26(5):474-8. DOI: 10.1001/archpsyc.1972.01750230084016. View

11.

Dencker S, Malm U, ROOS B, WERDINIUS B . Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. J Neurochem. 1966; 13(12):1545-8. DOI: 10.1111/j.1471-4159.1966.tb04320.x. View

12.

Brodie B, Davies J, Hynie S, Krishna G, Weiss B . Interrelationships of catecholamines with other endocrine systems. Pharmacol Rev. 1966; 18(1):273-89. View

13.

Akiskal H, McKinney Jr W . Overview of recent research in depression. Integration of ten conceptual models into a comprehensive clinical frame. Arch Gen Psychiatry. 1975; 32(3):285-305. DOI: 10.1001/archpsyc.1975.01760210019001. View

14.

Ashcroft G, Crawford T, Eccleston D, SHARMAN D, MACDOUGALL E, Stanton J . 5-hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet. 1966; 2(7472):1049-52. DOI: 10.1016/s0140-6736(66)92028-9. View

15.

MENDELS J, Frazer A, FITZGERALD R, Ramsey T, STOKES J . Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients. Science. 1972; 175(4028):1380-2. DOI: 10.1126/science.175.4028.1380. View

16.

Whybrow P, Prange Jr A, Treadway C . Mental changes accompanying thyroid gland dysfunction. A reappraisal using objective psychological measurement. Arch Gen Psychiatry. 1969; 20(1):48-63. DOI: 10.1001/archpsyc.1969.01740130050004. View

17.

van Praag H, Korf J, Schut D . Cerebral monoamines and depression. An investigation with the Probenecid technique. Arch Gen Psychiatry. 1973; 28(6):827-31. DOI: 10.1001/archpsyc.1973.01750360053007. View

18.

PAPESCHI R, McClure D . Homovanillic and 5-hydroxyindoleacetic acid in cerebrospinal fluid of depressed patients. Arch Gen Psychiatry. 1971; 25(4):354-8. DOI: 10.1001/archpsyc.1971.01750160066012. View

19.

Korf J . Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid. Clin Chim Acta. 1969; 26(2):301-6. DOI: 10.1016/0009-8981(69)90383-0. View

20.

Wheatley D . Potentiation of amitriptyline by thyroid hormone. Arch Gen Psychiatry. 1972; 26(3):229-33. DOI: 10.1001/archpsyc.1972.01750210037008. View